Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1

• Main Authors: Wang, L, Chan, C.E.L, Wong, A.L.-A, Wong, F.C, Lim, S.W, Chinnathambi, A, Alharbi, S.A, Lee, L.S.-U, Soo, R, Yong, W.P, Lee, S.C, Ho, P.C.-L, Sethi, G, Goh, B.C
• Other Authors: PHARMACY
• Format: Article
• Published: 2020
• Subjects: belinostat; firtecan; firtecan glucuronide; glucuronosyltransferase 1A1; irinotecan; Article; controlled study; drug glucuronidation; enzyme inactivation; enzyme inhibition; heterozygote; homozygote; human; human cell; in vitro study; incubation time; limit of quantitation; liquid chromatography-mass spectrometry; liver microsome; measurement accuracy; measurement precision
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/173804
• Institution: National University of Singapore

10.18632/oncotarget.15017