Valine/isoleucine variants drive selective pressure in the VP1 sequence of EV-A71 enteroviruses

• Main Authors: Duy, N.N, Huong, L.T.T, Ravel, P, Huong, L.T.S, Dwivedi, A, Sessions, O.M, Hou, Y.A, Chua, R, Kister, G, Afelt, A, Moulia, C, Gubler, D.J, Thiem, V.D, Thanh, N.T.H, Devaux, C, Duong, T.N, Hien, N.T, Cornillot, E, Gavotte, L, Frutos, R
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: BioMed Central Ltd. 2020
• Subjects: isoleucine; protein VP1; valine; capsid protein; VP1 protein, Foot-and-mouth disease virus; age; Article; child; controlled study; correlational study; correspondence analysis; disease severity; DNA polymorphism; Enterovirus A71; ethnicity; factorial correspondence analysis; female; gene mutation; gene sequence; genetic analysis; genetic variability; human; infant; major clinical study; male; nonhuman; nucleotide sequence; phylogeny; preschool child; school child; sequence alignment; spatiotemporal analysis; Viet Nam; virus gene; VP1 gene; Enterovirus; Enterovirus A; epidemic; genetic polymorphism; genetic selection; genetics; Hand, Foot and Mouth Disease; isolation and purification; mutation; pathogenicity; virology; Capsid Proteins; Child, Preschool; Disease Outbreaks; Enterovirus A, Human; Epidemics; Female; Humans; Infant; Isoleucine; Male; Mutation; Phylogeny; Polymorphism, Genetic; Selection, Genetic; Spatio-Temporal Analysis; Valine; Vietnam
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/173846
• Institution: National University of Singapore

10.1186/s12879-017-2427-4