Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells

• Main Authors: Itahana Y., Zhang J., Göke J., Vardy L.A., Han R., Iwamoto K., Cukuroglu E., Robson P., Pouladi M.A., Colman A., Itahana K.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: cyclin dependent kinase inhibitor 1A; histone; protein binding; protein p53; small interfering RNA; antagonists and inhibitors; cell differentiation; cell line; cytology; genetic epigenesis; genetics; human; human embryonic stem cell; indirect fluorescent antibody technique; induced pluripotent stem cell; metabolism; methylation; nucleotide sequence; promoter region; protein stability; RNA interference; transcription initiation; Base Sequence; Cell Differentiation; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Epigenesis, Genetic; Fluorescent Antibody Technique, Indirect; Histones; Human Embryonic Stem Cells; Humans; Induced Pluripotent Stem Cells; Methylation; Promoter Regions, Genetic; Protein Binding; Protein Stability; RNA Interference; RNA, Small Interfering; Transcriptional Activation; Tumor Suppressor Protein p53
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174005
• Institution: National University of Singapore

10.1038/srep28112