Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway

• Main Authors: Wang, T, Seah, S, Loh, X, Chan, C.-W, Hartman, M, Goh, B.-C, Lee, S.-C
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: 2020
• Subjects: caspase 3; farnesyl diphosphate; geranylgeranyl pyrophosphate; Ki 67 antigen; mammalian target of rapamycin; mevalonic acid; mitogen activated protein kinase; mitogen activated protein kinase 1; mitogen activated protein kinase 3; phosphatidylinositol 3 kinase; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; protein kinase B; Raf protein; simvastatin; hydroxymethylglutaryl coenzyme A reductase inhibitor; MTOR protein, human; target of rapamycin kinase; adult; antineoplastic activity; apoptosis; Article; breast cancer; breast cancer cell line; cell cycle; cell death; cell proliferation; clinical article; controlled study; enzyme inhibition; female; human; human cell; human tissue; in vitro study; prospective study; protein cleavage; protein dephosphorylation; signal transduction; aged; Breast Neoplasms; cancer grading; Carcinoma, Ductal, Breast; Carcinoma, Lobular; drug effects; enzyme immunoassay; gene expression regulation; metabolism; middle aged; pathology; prognosis; tumor cell culture; tumor invasion; Western blotting; Adult; Aged; Apoptosis; Blotting, Western; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoenzyme Techniques; Mevalonic Acid; Middle Aged; Mitogen-Activated Protein Kinases; Neoplasm Grading; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Prognosis; Prospective Studies; Proto-Oncogene Proteins c-akt; Simvastatin; TOR Serine-Threonine Kinases; Tumor Cells, Cultured
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174114
• Institution: National University of Singapore

10.18632/oncotarget.6304