Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway

10.18632/oncotarget.6304

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Main Authors:	Wang, T, Seah, S, Loh, X, Chan, C.-W, Hartman, M, Goh, B.-C, Lee, S.-C
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	2020
Subjects:	caspase 3 farnesyl diphosphate geranylgeranyl pyrophosphate Ki 67 antigen mammalian target of rapamycin mevalonic acid mitogen activated protein kinase mitogen activated protein kinase 1 mitogen activated protein kinase 3 phosphatidylinositol 3 kinase phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase protein kinase B Raf protein simvastatin hydroxymethylglutaryl coenzyme A reductase inhibitor MTOR protein, human target of rapamycin kinase adult antineoplastic activity apoptosis Article breast cancer breast cancer cell line cell cycle cell death cell proliferation clinical article controlled study enzyme inhibition female human human cell human tissue in vitro study prospective study protein cleavage protein dephosphorylation signal transduction aged Breast Neoplasms cancer grading Carcinoma, Ductal, Breast Carcinoma, Lobular drug effects enzyme immunoassay gene expression regulation metabolism middle aged pathology prognosis tumor cell culture tumor invasion Western blotting Adult Aged Apoptosis Blotting, Western Extracellular Signal-Regulated MAP Kinases Female Gene Expression Regulation, Neoplastic Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Immunoenzyme Techniques Mevalonic Acid Middle Aged Mitogen-Activated Protein Kinases Neoplasm Grading Neoplasm Invasiveness Phosphatidylinositol 3-Kinases Prognosis Prospective Studies Proto-Oncogene Proteins c-akt Simvastatin TOR Serine-Threonine Kinases Tumor Cells, Cultured
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174114
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1741142024-05-08T09:52:15Z Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway Wang, T Seah, S Loh, X Chan, C.-W Hartman, M Goh, B.-C Lee, S.-C CANCER SCIENCE INSTITUTE OF SINGAPORE SURGERY PHARMACOLOGY MEDICINE caspase 3 farnesyl diphosphate geranylgeranyl pyrophosphate Ki 67 antigen mammalian target of rapamycin mevalonic acid mitogen activated protein kinase mitogen activated protein kinase 1 mitogen activated protein kinase 3 phosphatidylinositol 3 kinase phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase protein kinase B Raf protein simvastatin hydroxymethylglutaryl coenzyme A reductase inhibitor mevalonic acid mitogen activated protein kinase MTOR protein, human phosphatidylinositol 3 kinase protein kinase B simvastatin target of rapamycin kinase adult antineoplastic activity apoptosis Article breast cancer breast cancer cell line cell cycle cell death cell proliferation clinical article controlled study enzyme inhibition female human human cell human tissue in vitro study prospective study protein cleavage protein dephosphorylation signal transduction aged Breast Neoplasms cancer grading Carcinoma, Ductal, Breast Carcinoma, Lobular drug effects enzyme immunoassay gene expression regulation metabolism middle aged pathology prognosis tumor cell culture tumor invasion Western blotting Adult Aged Apoptosis Blotting, Western Breast Neoplasms Carcinoma, Ductal, Breast Carcinoma, Lobular Extracellular Signal-Regulated MAP Kinases Female Gene Expression Regulation, Neoplastic Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Immunoenzyme Techniques Mevalonic Acid Middle Aged Mitogen-Activated Protein Kinases Neoplasm Grading Neoplasm Invasiveness Phosphatidylinositol 3-Kinases Prognosis Prospective Studies Proto-Oncogene Proteins c-akt Simvastatin TOR Serine-Threonine Kinases Tumor Cells, Cultured 10.18632/oncotarget.6304 Oncotarget 7 3 2532-2544 2020-09-03T10:32:36Z 2020-09-03T10:32:36Z 2016 Article Wang, T, Seah, S, Loh, X, Chan, C.-W, Hartman, M, Goh, B.-C, Lee, S.-C (2016). Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway. Oncotarget 7 (3) : 2532-2544. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.6304 19492553 https://scholarbank.nus.edu.sg/handle/10635/174114 Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	caspase 3 farnesyl diphosphate geranylgeranyl pyrophosphate Ki 67 antigen mammalian target of rapamycin mevalonic acid mitogen activated protein kinase mitogen activated protein kinase 1 mitogen activated protein kinase 3 phosphatidylinositol 3 kinase phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase protein kinase B Raf protein simvastatin hydroxymethylglutaryl coenzyme A reductase inhibitor mevalonic acid mitogen activated protein kinase MTOR protein, human phosphatidylinositol 3 kinase protein kinase B simvastatin target of rapamycin kinase adult antineoplastic activity apoptosis Article breast cancer breast cancer cell line cell cycle cell death cell proliferation clinical article controlled study enzyme inhibition female human human cell human tissue in vitro study prospective study protein cleavage protein dephosphorylation signal transduction aged Breast Neoplasms cancer grading Carcinoma, Ductal, Breast Carcinoma, Lobular drug effects enzyme immunoassay gene expression regulation metabolism middle aged pathology prognosis tumor cell culture tumor invasion Western blotting Adult Aged Apoptosis Blotting, Western Breast Neoplasms Carcinoma, Ductal, Breast Carcinoma, Lobular Extracellular Signal-Regulated MAP Kinases Female Gene Expression Regulation, Neoplastic Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Immunoenzyme Techniques Mevalonic Acid Middle Aged Mitogen-Activated Protein Kinases Neoplasm Grading Neoplasm Invasiveness Phosphatidylinositol 3-Kinases Prognosis Prospective Studies Proto-Oncogene Proteins c-akt Simvastatin TOR Serine-Threonine Kinases Tumor Cells, Cultured
spellingShingle	caspase 3 farnesyl diphosphate geranylgeranyl pyrophosphate Ki 67 antigen mammalian target of rapamycin mevalonic acid mitogen activated protein kinase mitogen activated protein kinase 1 mitogen activated protein kinase 3 phosphatidylinositol 3 kinase phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase protein kinase B Raf protein simvastatin hydroxymethylglutaryl coenzyme A reductase inhibitor mevalonic acid mitogen activated protein kinase MTOR protein, human phosphatidylinositol 3 kinase protein kinase B simvastatin target of rapamycin kinase adult antineoplastic activity apoptosis Article breast cancer breast cancer cell line cell cycle cell death cell proliferation clinical article controlled study enzyme inhibition female human human cell human tissue in vitro study prospective study protein cleavage protein dephosphorylation signal transduction aged Breast Neoplasms cancer grading Carcinoma, Ductal, Breast Carcinoma, Lobular drug effects enzyme immunoassay gene expression regulation metabolism middle aged pathology prognosis tumor cell culture tumor invasion Western blotting Adult Aged Apoptosis Blotting, Western Breast Neoplasms Carcinoma, Ductal, Breast Carcinoma, Lobular Extracellular Signal-Regulated MAP Kinases Female Gene Expression Regulation, Neoplastic Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Immunoenzyme Techniques Mevalonic Acid Middle Aged Mitogen-Activated Protein Kinases Neoplasm Grading Neoplasm Invasiveness Phosphatidylinositol 3-Kinases Prognosis Prospective Studies Proto-Oncogene Proteins c-akt Simvastatin TOR Serine-Threonine Kinases Tumor Cells, Cultured Wang, T Seah, S Loh, X Chan, C.-W Hartman, M Goh, B.-C Lee, S.-C Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway
description	10.18632/oncotarget.6304
author2	CANCER SCIENCE INSTITUTE OF SINGAPORE
author_facet	CANCER SCIENCE INSTITUTE OF SINGAPORE Wang, T Seah, S Loh, X Chan, C.-W Hartman, M Goh, B.-C Lee, S.-C
format	Article
author	Wang, T Seah, S Loh, X Chan, C.-W Hartman, M Goh, B.-C Lee, S.-C
author_sort	Wang, T
title	Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway
title_short	Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway
title_full	Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway
title_fullStr	Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway
title_full_unstemmed	Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway
title_sort	simvastatin-induced breast cancer cell death and deactivation of pi3k/akt and mapk/erk signalling are reversed by metabolic products of the mevalonate pathway
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174114
_version_	1800914215058276352

Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway

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