PRIMA-1met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms
10.18632/oncotarget.5385
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sg-nus-scholar.10635-1741322024-04-24T05:49:30Z PRIMA-1met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms Li, X.-L Zhou, J Chan, Z.-L Chooi, J.-Y Chen, Z.-R Chng, W.-J CANCER SCIENCE INSTITUTE OF SINGAPORE MEDICINE antineoplastic agent prima 1 met protein Noxa protein p53 PUMA protein unclassified drug 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one protein p53 quinuclidine derivative TP53 protein, human animal experiment animal model apoptosis Article cancer growth cancer inhibition cell migration cell proliferation clinical effectiveness colony formation colorectal cancer controlled study dose response female human human cell mouse nonhuman protein expression treatment duration treatment response upregulation animal Caco-2 cell line Colorectal Neoplasms disease model drug effects drug screening genetics HT-29 cell line metabolism nonobese diabetic mouse pathology SCID mouse Animals Caco-2 Cells Cell Proliferation Colorectal Neoplasms Disease Models, Animal HT29 Cells Humans Mice Mice, Inbred NOD Mice, SCID Quinuclidines Tumor Suppressor Protein p53 Xenograft Model Antitumor Assays 10.18632/oncotarget.5385 Oncotarget 6 34 36689-36699 2020-09-03T10:35:45Z 2020-09-03T10:35:45Z 2015 Article Li, X.-L, Zhou, J, Chan, Z.-L, Chooi, J.-Y, Chen, Z.-R, Chng, W.-J (2015). PRIMA-1met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms. Oncotarget 6 (34) : 36689-36699. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.5385 19492553 https://scholarbank.nus.edu.sg/handle/10635/174132 Unpaywall 20200831 |
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antineoplastic agent prima 1 met protein Noxa protein p53 PUMA protein unclassified drug 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one protein p53 quinuclidine derivative TP53 protein, human animal experiment animal model apoptosis Article cancer growth cancer inhibition cell migration cell proliferation clinical effectiveness colony formation colorectal cancer controlled study dose response female human human cell mouse nonhuman protein expression treatment duration treatment response upregulation animal Caco-2 cell line Colorectal Neoplasms disease model drug effects drug screening genetics HT-29 cell line metabolism nonobese diabetic mouse pathology SCID mouse Animals Caco-2 Cells Cell Proliferation Colorectal Neoplasms Disease Models, Animal HT29 Cells Humans Mice Mice, Inbred NOD Mice, SCID Quinuclidines Tumor Suppressor Protein p53 Xenograft Model Antitumor Assays |
| spellingShingle |
antineoplastic agent prima 1 met protein Noxa protein p53 PUMA protein unclassified drug 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one protein p53 quinuclidine derivative TP53 protein, human animal experiment animal model apoptosis Article cancer growth cancer inhibition cell migration cell proliferation clinical effectiveness colony formation colorectal cancer controlled study dose response female human human cell mouse nonhuman protein expression treatment duration treatment response upregulation animal Caco-2 cell line Colorectal Neoplasms disease model drug effects drug screening genetics HT-29 cell line metabolism nonobese diabetic mouse pathology SCID mouse Animals Caco-2 Cells Cell Proliferation Colorectal Neoplasms Disease Models, Animal HT29 Cells Humans Mice Mice, Inbred NOD Mice, SCID Quinuclidines Tumor Suppressor Protein p53 Xenograft Model Antitumor Assays Li, X.-L Zhou, J Chan, Z.-L Chooi, J.-Y Chen, Z.-R Chng, W.-J PRIMA-1met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms |
| description |
10.18632/oncotarget.5385 |
| author2 |
CANCER SCIENCE INSTITUTE OF SINGAPORE |
| author_facet |
CANCER SCIENCE INSTITUTE OF SINGAPORE Li, X.-L Zhou, J Chan, Z.-L Chooi, J.-Y Chen, Z.-R Chng, W.-J |
| format |
Article |
| author |
Li, X.-L Zhou, J Chan, Z.-L Chooi, J.-Y Chen, Z.-R Chng, W.-J |
| author_sort |
Li, X.-L |
| title |
PRIMA-1met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms |
| title_short |
PRIMA-1met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms |
| title_full |
PRIMA-1met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms |
| title_fullStr |
PRIMA-1met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms |
| title_full_unstemmed |
PRIMA-1met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms |
| title_sort |
prima-1met (apr-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms |
| publishDate |
2020 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/174132 |
| _version_ |
1800914217549692928 |