Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma

Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma

10.18632/oncotarget.5031

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Bibliographic Details
Main Authors:	Chua, K.N, Kong, L.R, Sim, W.J, Ng, H.C, Ong, W.R, Thiery, J.P, Huynh, H, Goh, B.C
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	2020
Subjects:	focal adhesion kinase n (2,3 dihydroxypropoxy) 3,4 difluoro 2 (2 fluoro 4 iodoanilino)benzamide paxillin plakoglobin saracatinib transcription factor Snail uvomorulin 1,3 benzodioxole derivative benzamide derivative cadherin diphenylamine mitogen activated protein kinase kinase 1 protein kinase inhibitor protein tyrosine kinase quinazoline derivative anchorage independent growth animal cell animal experiment animal model animal tissue Article cancer control cancer growth cancer inhibition carcinogenicity cell invasion cell migration cell proliferation controlled study drug potentiation epithelial mesenchymal transition female G1 phase cell cycle checkpoint lung cancer cell line mouse non small cell lung cancer nonhuman protein expression protein localization tumor xenograft analogs and derivatives animal antagonists and inhibitors Bagg albino mouse Carcinoma, Non-Small-Cell Lung cell adhesion cell cycle cell motion confocal microscopy dose response drug effects drug screening enzymology human immunoblotting Lung Neoplasms metabolism nude mouse pathology tumor volume Animals Benzamides Benzodioxoles Cadherins Cell Adhesion Cell Cycle Cell Movement Cell Proliferation Diphenylamine Dose-Response Relationship, Drug Drug Synergism Epithelial-Mesenchymal Transition Female Humans Immunoblotting MAP Kinase Kinase 1 Mice, Inbred BALB C Mice, Nude Microscopy, Confocal Protein Kinase Inhibitors Quinazolines src-Family Kinases Tumor Burden Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174135
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Institution:	National University of Singapore

Description
Summary:	10.18632/oncotarget.5031