Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma

10.18632/oncotarget.5031

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Main Authors:	Chua, K.N, Kong, L.R, Sim, W.J, Ng, H.C, Ong, W.R, Thiery, J.P, Huynh, H, Goh, B.C
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	2020
Subjects:	focal adhesion kinase n (2,3 dihydroxypropoxy) 3,4 difluoro 2 (2 fluoro 4 iodoanilino)benzamide paxillin plakoglobin saracatinib transcription factor Snail uvomorulin 1,3 benzodioxole derivative benzamide derivative cadherin diphenylamine mitogen activated protein kinase kinase 1 protein kinase inhibitor protein tyrosine kinase quinazoline derivative anchorage independent growth animal cell animal experiment animal model animal tissue Article cancer control cancer growth cancer inhibition carcinogenicity cell invasion cell migration cell proliferation controlled study drug potentiation epithelial mesenchymal transition female G1 phase cell cycle checkpoint lung cancer cell line mouse non small cell lung cancer nonhuman protein expression protein localization tumor xenograft analogs and derivatives animal antagonists and inhibitors Bagg albino mouse Carcinoma, Non-Small-Cell Lung cell adhesion cell cycle cell motion confocal microscopy dose response drug effects drug screening enzymology human immunoblotting Lung Neoplasms metabolism nude mouse pathology tumor volume Animals Benzamides Benzodioxoles Cadherins Cell Adhesion Cell Cycle Cell Movement Cell Proliferation Diphenylamine Dose-Response Relationship, Drug Drug Synergism Epithelial-Mesenchymal Transition Female Humans Immunoblotting MAP Kinase Kinase 1 Mice, Inbred BALB C Mice, Nude Microscopy, Confocal Protein Kinase Inhibitors Quinazolines src-Family Kinases Tumor Burden Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174135
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1741352024-05-08T09:52:15Z Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma Chua, K.N Kong, L.R Sim, W.J Ng, H.C Ong, W.R Thiery, J.P Huynh, H Goh, B.C CANCER SCIENCE INSTITUTE OF SINGAPORE BIOMED INST FOR GLOBAL HEALTH RES & TECH BIOCHEMISTRY MEDICINE PHARMACOLOGY focal adhesion kinase n (2,3 dihydroxypropoxy) 3,4 difluoro 2 (2 fluoro 4 iodoanilino)benzamide paxillin plakoglobin saracatinib transcription factor Snail uvomorulin 1,3 benzodioxole derivative benzamide derivative cadherin diphenylamine mitogen activated protein kinase kinase 1 n (2,3 dihydroxypropoxy) 3,4 difluoro 2 (2 fluoro 4 iodoanilino)benzamide protein kinase inhibitor protein tyrosine kinase quinazoline derivative saracatinib anchorage independent growth animal cell animal experiment animal model animal tissue Article cancer control cancer growth cancer inhibition carcinogenicity cell invasion cell migration cell proliferation controlled study drug potentiation epithelial mesenchymal transition female G1 phase cell cycle checkpoint lung cancer cell line mouse non small cell lung cancer nonhuman protein expression protein localization tumor xenograft analogs and derivatives animal antagonists and inhibitors Bagg albino mouse Carcinoma, Non-Small-Cell Lung cell adhesion cell cycle cell motion confocal microscopy dose response drug effects drug potentiation drug screening enzymology epithelial mesenchymal transition human immunoblotting Lung Neoplasms metabolism nude mouse pathology tumor volume Animals Benzamides Benzodioxoles Cadherins Carcinoma, Non-Small-Cell Lung Cell Adhesion Cell Cycle Cell Movement Cell Proliferation Diphenylamine Dose-Response Relationship, Drug Drug Synergism Epithelial-Mesenchymal Transition Female Humans Immunoblotting Lung Neoplasms MAP Kinase Kinase 1 Mice, Inbred BALB C Mice, Nude Microscopy, Confocal Protein Kinase Inhibitors Quinazolines src-Family Kinases Tumor Burden Xenograft Model Antitumor Assays 10.18632/oncotarget.5031 Oncotarget 6 30 29991-30005 2020-09-03T10:36:20Z 2020-09-03T10:36:20Z 2015 Article Chua, K.N, Kong, L.R, Sim, W.J, Ng, H.C, Ong, W.R, Thiery, J.P, Huynh, H, Goh, B.C (2015). Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma. Oncotarget 6 (30) : 29991-30005. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.5031 19492553 https://scholarbank.nus.edu.sg/handle/10635/174135 Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	focal adhesion kinase n (2,3 dihydroxypropoxy) 3,4 difluoro 2 (2 fluoro 4 iodoanilino)benzamide paxillin plakoglobin saracatinib transcription factor Snail uvomorulin 1,3 benzodioxole derivative benzamide derivative cadherin diphenylamine mitogen activated protein kinase kinase 1 n (2,3 dihydroxypropoxy) 3,4 difluoro 2 (2 fluoro 4 iodoanilino)benzamide protein kinase inhibitor protein tyrosine kinase quinazoline derivative saracatinib anchorage independent growth animal cell animal experiment animal model animal tissue Article cancer control cancer growth cancer inhibition carcinogenicity cell invasion cell migration cell proliferation controlled study drug potentiation epithelial mesenchymal transition female G1 phase cell cycle checkpoint lung cancer cell line mouse non small cell lung cancer nonhuman protein expression protein localization tumor xenograft analogs and derivatives animal antagonists and inhibitors Bagg albino mouse Carcinoma, Non-Small-Cell Lung cell adhesion cell cycle cell motion confocal microscopy dose response drug effects drug potentiation drug screening enzymology epithelial mesenchymal transition human immunoblotting Lung Neoplasms metabolism nude mouse pathology tumor volume Animals Benzamides Benzodioxoles Cadherins Carcinoma, Non-Small-Cell Lung Cell Adhesion Cell Cycle Cell Movement Cell Proliferation Diphenylamine Dose-Response Relationship, Drug Drug Synergism Epithelial-Mesenchymal Transition Female Humans Immunoblotting Lung Neoplasms MAP Kinase Kinase 1 Mice, Inbred BALB C Mice, Nude Microscopy, Confocal Protein Kinase Inhibitors Quinazolines src-Family Kinases Tumor Burden Xenograft Model Antitumor Assays
spellingShingle	focal adhesion kinase n (2,3 dihydroxypropoxy) 3,4 difluoro 2 (2 fluoro 4 iodoanilino)benzamide paxillin plakoglobin saracatinib transcription factor Snail uvomorulin 1,3 benzodioxole derivative benzamide derivative cadherin diphenylamine mitogen activated protein kinase kinase 1 n (2,3 dihydroxypropoxy) 3,4 difluoro 2 (2 fluoro 4 iodoanilino)benzamide protein kinase inhibitor protein tyrosine kinase quinazoline derivative saracatinib anchorage independent growth animal cell animal experiment animal model animal tissue Article cancer control cancer growth cancer inhibition carcinogenicity cell invasion cell migration cell proliferation controlled study drug potentiation epithelial mesenchymal transition female G1 phase cell cycle checkpoint lung cancer cell line mouse non small cell lung cancer nonhuman protein expression protein localization tumor xenograft analogs and derivatives animal antagonists and inhibitors Bagg albino mouse Carcinoma, Non-Small-Cell Lung cell adhesion cell cycle cell motion confocal microscopy dose response drug effects drug potentiation drug screening enzymology epithelial mesenchymal transition human immunoblotting Lung Neoplasms metabolism nude mouse pathology tumor volume Animals Benzamides Benzodioxoles Cadherins Carcinoma, Non-Small-Cell Lung Cell Adhesion Cell Cycle Cell Movement Cell Proliferation Diphenylamine Dose-Response Relationship, Drug Drug Synergism Epithelial-Mesenchymal Transition Female Humans Immunoblotting Lung Neoplasms MAP Kinase Kinase 1 Mice, Inbred BALB C Mice, Nude Microscopy, Confocal Protein Kinase Inhibitors Quinazolines src-Family Kinases Tumor Burden Xenograft Model Antitumor Assays Chua, K.N Kong, L.R Sim, W.J Ng, H.C Ong, W.R Thiery, J.P Huynh, H Goh, B.C Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma
description	10.18632/oncotarget.5031
author2	CANCER SCIENCE INSTITUTE OF SINGAPORE
author_facet	CANCER SCIENCE INSTITUTE OF SINGAPORE Chua, K.N Kong, L.R Sim, W.J Ng, H.C Ong, W.R Thiery, J.P Huynh, H Goh, B.C
format	Article
author	Chua, K.N Kong, L.R Sim, W.J Ng, H.C Ong, W.R Thiery, J.P Huynh, H Goh, B.C
author_sort	Chua, K.N
title	Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma
title_short	Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma
title_full	Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma
title_fullStr	Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma
title_full_unstemmed	Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma
title_sort	combinatorial treatment using targeted mek and src inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174135
_version_	1800914217725853696

Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma

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