Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma

• Main Authors: Chua, K.N, Kong, L.R, Sim, W.J, Ng, H.C, Ong, W.R, Thiery, J.P, Huynh, H, Goh, B.C
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: 2020
• Subjects: focal adhesion kinase; n (2,3 dihydroxypropoxy) 3,4 difluoro 2 (2 fluoro 4 iodoanilino)benzamide; paxillin; plakoglobin; saracatinib; transcription factor Snail; uvomorulin; 1,3 benzodioxole derivative; benzamide derivative; cadherin; diphenylamine; mitogen activated protein kinase kinase 1; protein kinase inhibitor; protein tyrosine kinase; quinazoline derivative; anchorage independent growth; animal cell; animal experiment; animal model; animal tissue; Article; cancer control; cancer growth; cancer inhibition; carcinogenicity; cell invasion; cell migration; cell proliferation; controlled study; drug potentiation; epithelial mesenchymal transition; female; G1 phase cell cycle checkpoint; lung cancer cell line; mouse; non small cell lung cancer; nonhuman; protein expression; protein localization; tumor xenograft; analogs and derivatives; animal; antagonists and inhibitors; Bagg albino mouse; Carcinoma, Non-Small-Cell Lung; cell adhesion; cell cycle; cell motion; confocal microscopy; dose response; drug effects; drug screening; enzymology; human; immunoblotting; Lung Neoplasms; metabolism; nude mouse; pathology; tumor volume; Animals; Benzamides; Benzodioxoles; Cadherins; Cell Adhesion; Cell Cycle; Cell Movement; Cell Proliferation; Diphenylamine; Dose-Response Relationship, Drug; Drug Synergism; Epithelial-Mesenchymal Transition; Female; Humans; Immunoblotting; MAP Kinase Kinase 1; Mice, Inbred BALB C; Mice, Nude; Microscopy, Confocal; Protein Kinase Inhibitors; Quinazolines; src-Family Kinases; Tumor Burden; Xenograft Model Antitumor Assays
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174135
• Institution: National University of Singapore

10.18632/oncotarget.5031