?-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model

• Main Authors: Siveen K.S., Ahn K.S., Ong T.H., Shanmugam M.K., Li F., Yap W.N., Kumar A.P., Fong C.W., Tergaonkar V., Hui K.M., Sethi G.
• Other Authors: PHARMACOLOGY
• Format: Article
• Published: 2020
• Subjects: caspase 3; CD31 antigen; gamma tocotrienol; Ki 67 antigen; mammalian target of rapamycin; matrigel; protein kinase B; vasculotropin; vasculotropin receptor 2; alpha tocopherol; antineoplastic agent; chroman derivative; plastochromanol 8; vasculotropin A; angiogenesis; animal experiment; animal model; animal tissue; antiangiogenic activity; antineoplastic activity; article; autophosphorylation; cancer inhibition; cancer tissue; capillary sprouting; cell invasion; cell viability; cellular parameters; chorioallantois; concentration response; controlled study; drug efficacy; embryo; enzyme inhibition; female; human; human cell; in vitro study; in vivo study; liver cell carcinoma; migration inhibition; mouse; nonhuman; rat; signal transduction; thoracic aorta; tube formation; tumor xenograft; umbilical vein endothelial cell; vascular ring; analogs and derivatives; animal; apoptosis; Carcinoma, Hepatocellular; cell motion; cell proliferation; cell survival; chemistry; chick embryo; drug effects; endothelium cell; Liver Neoplasms; metabolism; Neovascularization, Pathologic; SCID mouse; tumor cell line; vascularization; Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Chick Embryo; Chromans; Endothelial Cells; Humans; Ki-67 Antigen; Mice; Mice, SCID; Models, Animal; Proto-Oncogene Proteins c-akt; Signal Transduction; Vascular Endothelial Growth Factor A; Vitamin E
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174170
• Institution: National University of Singapore

10.18632/oncotarget.1876