?-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model

10.18632/oncotarget.1876

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Main Authors:	Siveen K.S., Ahn K.S., Ong T.H., Shanmugam M.K., Li F., Yap W.N., Kumar A.P., Fong C.W., Tergaonkar V., Hui K.M., Sethi G.
Other Authors:	PHARMACOLOGY
Format:	Article
Published:	2020
Subjects:	caspase 3 CD31 antigen gamma tocotrienol Ki 67 antigen mammalian target of rapamycin matrigel protein kinase B vasculotropin vasculotropin receptor 2 alpha tocopherol antineoplastic agent chroman derivative plastochromanol 8 vasculotropin A angiogenesis animal experiment animal model animal tissue antiangiogenic activity antineoplastic activity article autophosphorylation cancer inhibition cancer tissue capillary sprouting cell invasion cell viability cellular parameters chorioallantois concentration response controlled study drug efficacy embryo enzyme inhibition female human human cell in vitro study in vivo study liver cell carcinoma migration inhibition mouse nonhuman rat signal transduction thoracic aorta tube formation tumor xenograft umbilical vein endothelial cell vascular ring analogs and derivatives animal apoptosis Carcinoma, Hepatocellular cell motion cell proliferation cell survival chemistry chick embryo drug effects endothelium cell Liver Neoplasms metabolism Neovascularization, Pathologic SCID mouse tumor cell line vascularization Animals Antineoplastic Agents Apoptosis Caspase 3 Cell Line, Tumor Cell Movement Cell Proliferation Cell Survival Chick Embryo Chromans Endothelial Cells Humans Ki-67 Antigen Mice Mice, SCID Models, Animal Proto-Oncogene Proteins c-akt Signal Transduction Vascular Endothelial Growth Factor A Vitamin E
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174170
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1741702024-04-22T03:33:37Z ?-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model Siveen K.S. Ahn K.S. Ong T.H. Shanmugam M.K. Li F. Yap W.N. Kumar A.P. Fong C.W. Tergaonkar V. Hui K.M. Sethi G. PHARMACOLOGY CANCER SCIENCE INSTITUTE OF SINGAPORE BIOCHEMISTRY DUKE-NUS MEDICAL SCHOOL caspase 3 CD31 antigen gamma tocotrienol Ki 67 antigen mammalian target of rapamycin matrigel protein kinase B vasculotropin vasculotropin receptor 2 alpha tocopherol antineoplastic agent caspase 3 chroman derivative Ki 67 antigen plastochromanol 8 protein kinase B vasculotropin A angiogenesis animal experiment animal model animal tissue antiangiogenic activity antineoplastic activity article autophosphorylation cancer inhibition cancer tissue capillary sprouting cell invasion cell viability cellular parameters chorioallantois concentration response controlled study drug efficacy embryo enzyme inhibition female human human cell in vitro study in vivo study liver cell carcinoma migration inhibition mouse nonhuman rat signal transduction thoracic aorta tube formation tumor xenograft umbilical vein endothelial cell vascular ring analogs and derivatives animal apoptosis Carcinoma, Hepatocellular cell motion cell proliferation cell survival chemistry chick embryo drug effects endothelium cell Liver Neoplasms metabolism Neovascularization, Pathologic SCID mouse signal transduction tumor cell line vascularization Animals Antineoplastic Agents Apoptosis Carcinoma, Hepatocellular Caspase 3 Cell Line, Tumor Cell Movement Cell Proliferation Cell Survival Chick Embryo Chromans Endothelial Cells Humans Ki-67 Antigen Liver Neoplasms Mice Mice, SCID Models, Animal Neovascularization, Pathologic Proto-Oncogene Proteins c-akt Signal Transduction Vascular Endothelial Growth Factor A Vitamin E 10.18632/oncotarget.1876 Oncotarget 5 7 1897-1911 2020-09-03T10:42:31Z 2020-09-03T10:42:31Z 2014 Article Siveen K.S., Ahn K.S., Ong T.H., Shanmugam M.K., Li F., Yap W.N., Kumar A.P., Fong C.W., Tergaonkar V., Hui K.M., Sethi G. (2014). ?-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model. Oncotarget 5 (7) : 1897-1911. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.1876 19492553 https://scholarbank.nus.edu.sg/handle/10635/174170 Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	caspase 3 CD31 antigen gamma tocotrienol Ki 67 antigen mammalian target of rapamycin matrigel protein kinase B vasculotropin vasculotropin receptor 2 alpha tocopherol antineoplastic agent caspase 3 chroman derivative Ki 67 antigen plastochromanol 8 protein kinase B vasculotropin A angiogenesis animal experiment animal model animal tissue antiangiogenic activity antineoplastic activity article autophosphorylation cancer inhibition cancer tissue capillary sprouting cell invasion cell viability cellular parameters chorioallantois concentration response controlled study drug efficacy embryo enzyme inhibition female human human cell in vitro study in vivo study liver cell carcinoma migration inhibition mouse nonhuman rat signal transduction thoracic aorta tube formation tumor xenograft umbilical vein endothelial cell vascular ring analogs and derivatives animal apoptosis Carcinoma, Hepatocellular cell motion cell proliferation cell survival chemistry chick embryo drug effects endothelium cell Liver Neoplasms metabolism Neovascularization, Pathologic SCID mouse signal transduction tumor cell line vascularization Animals Antineoplastic Agents Apoptosis Carcinoma, Hepatocellular Caspase 3 Cell Line, Tumor Cell Movement Cell Proliferation Cell Survival Chick Embryo Chromans Endothelial Cells Humans Ki-67 Antigen Liver Neoplasms Mice Mice, SCID Models, Animal Neovascularization, Pathologic Proto-Oncogene Proteins c-akt Signal Transduction Vascular Endothelial Growth Factor A Vitamin E
spellingShingle	caspase 3 CD31 antigen gamma tocotrienol Ki 67 antigen mammalian target of rapamycin matrigel protein kinase B vasculotropin vasculotropin receptor 2 alpha tocopherol antineoplastic agent caspase 3 chroman derivative Ki 67 antigen plastochromanol 8 protein kinase B vasculotropin A angiogenesis animal experiment animal model animal tissue antiangiogenic activity antineoplastic activity article autophosphorylation cancer inhibition cancer tissue capillary sprouting cell invasion cell viability cellular parameters chorioallantois concentration response controlled study drug efficacy embryo enzyme inhibition female human human cell in vitro study in vivo study liver cell carcinoma migration inhibition mouse nonhuman rat signal transduction thoracic aorta tube formation tumor xenograft umbilical vein endothelial cell vascular ring analogs and derivatives animal apoptosis Carcinoma, Hepatocellular cell motion cell proliferation cell survival chemistry chick embryo drug effects endothelium cell Liver Neoplasms metabolism Neovascularization, Pathologic SCID mouse signal transduction tumor cell line vascularization Animals Antineoplastic Agents Apoptosis Carcinoma, Hepatocellular Caspase 3 Cell Line, Tumor Cell Movement Cell Proliferation Cell Survival Chick Embryo Chromans Endothelial Cells Humans Ki-67 Antigen Liver Neoplasms Mice Mice, SCID Models, Animal Neovascularization, Pathologic Proto-Oncogene Proteins c-akt Signal Transduction Vascular Endothelial Growth Factor A Vitamin E Siveen K.S. Ahn K.S. Ong T.H. Shanmugam M.K. Li F. Yap W.N. Kumar A.P. Fong C.W. Tergaonkar V. Hui K.M. Sethi G. ?-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model
description	10.18632/oncotarget.1876
author2	PHARMACOLOGY
author_facet	PHARMACOLOGY Siveen K.S. Ahn K.S. Ong T.H. Shanmugam M.K. Li F. Yap W.N. Kumar A.P. Fong C.W. Tergaonkar V. Hui K.M. Sethi G.
format	Article
author	Siveen K.S. Ahn K.S. Ong T.H. Shanmugam M.K. Li F. Yap W.N. Kumar A.P. Fong C.W. Tergaonkar V. Hui K.M. Sethi G.
author_sort	Siveen K.S.
title	?-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model
title_short	?-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model
title_full	?-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model
title_fullStr	?-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model
title_full_unstemmed	?-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model
title_sort	?-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of akt/mtor pathway in an orthotopic mouse model
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174170
_version_	1800914220942884864

?-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model

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