Isorhynchophylline, a potent plant alkaloid, induces apoptotic and anti-metastatic effects in human hepatocellular carcinoma cells through the modulation of diverse cell signaling cascades

• Main Authors: Lee, H, Baek, S.H, Lee, J.H, Kim, C, Ko, J.-H, Lee, S.-G, Chinnathambi, A, Alharbi, S.A, Yang, W.M, Um, J.-Y, Sethi, G, Ahn, K.S
• Other Authors: DEPT OF PHARMACOLOGY
• Format: Article
• Published: MDPI 2020
• Subjects: caspase 3; caspase 8; caspase 9; chemokine receptor CXCR4; cyclic AMP responsive element binding protein; gelatinase A; gelatinase B; isorhynchophylline; lipocortin 5; mitogen activated protein kinase; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; protein kinase B; protein p53; STAT3 protein; stress activated protein kinase; synaptophysin; vasculotropin; antineoplastic agent; indole alkaloid; rhynchophylline; antineoplastic activity; apoptosis; Article; cell cycle assay; cell invasion assay; cell migration; cell proliferation; cell signaling; controlled study; down regulation; enzyme activation; enzyme phosphorylation; genetic transfection; human; human cell; liver cell carcinoma; MTT assay; protein binding; protein expression; signal transduction; TUNEL assay; Uncaria; Western blotting; wound healing assay; cell motion; chemistry; drug effects; Hep-G2 cell line; liver tumor; metabolism; metastasis; pathology; tumor cell line; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Hep G2 Cells; Humans; Indole Alkaloids; Liver Neoplasms; Neoplasm Metastasis; Signal Transduction
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/183525
• Institution: National University of Singapore

10.3390/ijms18051095