Isorhynchophylline, a potent plant alkaloid, induces apoptotic and anti-metastatic effects in human hepatocellular carcinoma cells through the modulation of diverse cell signaling cascades

10.3390/ijms18051095

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Main Authors:	Lee, H, Baek, S.H, Lee, J.H, Kim, C, Ko, J.-H, Lee, S.-G, Chinnathambi, A, Alharbi, S.A, Yang, W.M, Um, J.-Y, Sethi, G, Ahn, K.S
Other Authors:	PHARMACOLOGY
Format:	Article
Published:	MDPI 2020
Subjects:	caspase 3 caspase 8 caspase 9 chemokine receptor CXCR4 cyclic AMP responsive element binding protein gelatinase A gelatinase B isorhynchophylline lipocortin 5 mitogen activated protein kinase nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase protein kinase B protein p53 STAT3 protein stress activated protein kinase synaptophysin vasculotropin antineoplastic agent indole alkaloid rhynchophylline antineoplastic activity apoptosis Article cell cycle assay cell invasion assay cell migration cell proliferation cell signaling controlled study down regulation enzyme activation enzyme phosphorylation genetic transfection human human cell liver cell carcinoma MTT assay protein binding protein expression signal transduction TUNEL assay Uncaria Western blotting wound healing assay cell motion chemistry drug effects Hep-G2 cell line liver tumor metabolism metastasis pathology tumor cell line Antineoplastic Agents, Phytogenic Apoptosis Carcinoma, Hepatocellular Cell Line, Tumor Cell Movement Cell Proliferation Hep G2 Cells Humans Indole Alkaloids Liver Neoplasms Neoplasm Metastasis Signal Transduction
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/183525
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1835252024-11-12T00:36:55Z Isorhynchophylline, a potent plant alkaloid, induces apoptotic and anti-metastatic effects in human hepatocellular carcinoma cells through the modulation of diverse cell signaling cascades Lee, H Baek, S.H Lee, J.H Kim, C Ko, J.-H Lee, S.-G Chinnathambi, A Alharbi, S.A Yang, W.M Um, J.-Y Sethi, G Ahn, K.S PHARMACOLOGY caspase 3 caspase 8 caspase 9 chemokine receptor CXCR4 cyclic AMP responsive element binding protein gelatinase A gelatinase B isorhynchophylline lipocortin 5 mitogen activated protein kinase nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase protein kinase B protein p53 STAT3 protein stress activated protein kinase synaptophysin vasculotropin antineoplastic agent indole alkaloid rhynchophylline antineoplastic activity apoptosis Article cell cycle assay cell invasion assay cell migration cell proliferation cell signaling controlled study down regulation enzyme activation enzyme phosphorylation genetic transfection human human cell liver cell carcinoma MTT assay protein binding protein expression signal transduction TUNEL assay Uncaria Western blotting wound healing assay apoptosis cell motion chemistry drug effects Hep-G2 cell line liver cell carcinoma liver tumor metabolism metastasis pathology signal transduction tumor cell line Antineoplastic Agents, Phytogenic Apoptosis Carcinoma, Hepatocellular Cell Line, Tumor Cell Movement Cell Proliferation Hep G2 Cells Humans Indole Alkaloids Liver Neoplasms Neoplasm Metastasis Signal Transduction Uncaria 10.3390/ijms18051095 International Journal of Molecular Sciences 18 5 1095 2020-11-17T04:42:31Z 2020-11-17T04:42:31Z 2017 Article Lee, H, Baek, S.H, Lee, J.H, Kim, C, Ko, J.-H, Lee, S.-G, Chinnathambi, A, Alharbi, S.A, Yang, W.M, Um, J.-Y, Sethi, G, Ahn, K.S (2017). Isorhynchophylline, a potent plant alkaloid, induces apoptotic and anti-metastatic effects in human hepatocellular carcinoma cells through the modulation of diverse cell signaling cascades. International Journal of Molecular Sciences 18 (5) : 1095. ScholarBank@NUS Repository. https://doi.org/10.3390/ijms18051095 1661-6596 https://scholarbank.nus.edu.sg/handle/10635/183525 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ MDPI Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	caspase 3 caspase 8 caspase 9 chemokine receptor CXCR4 cyclic AMP responsive element binding protein gelatinase A gelatinase B isorhynchophylline lipocortin 5 mitogen activated protein kinase nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase protein kinase B protein p53 STAT3 protein stress activated protein kinase synaptophysin vasculotropin antineoplastic agent indole alkaloid rhynchophylline antineoplastic activity apoptosis Article cell cycle assay cell invasion assay cell migration cell proliferation cell signaling controlled study down regulation enzyme activation enzyme phosphorylation genetic transfection human human cell liver cell carcinoma MTT assay protein binding protein expression signal transduction TUNEL assay Uncaria Western blotting wound healing assay apoptosis cell motion chemistry drug effects Hep-G2 cell line liver cell carcinoma liver tumor metabolism metastasis pathology signal transduction tumor cell line Antineoplastic Agents, Phytogenic Apoptosis Carcinoma, Hepatocellular Cell Line, Tumor Cell Movement Cell Proliferation Hep G2 Cells Humans Indole Alkaloids Liver Neoplasms Neoplasm Metastasis Signal Transduction Uncaria
spellingShingle	caspase 3 caspase 8 caspase 9 chemokine receptor CXCR4 cyclic AMP responsive element binding protein gelatinase A gelatinase B isorhynchophylline lipocortin 5 mitogen activated protein kinase nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase protein kinase B protein p53 STAT3 protein stress activated protein kinase synaptophysin vasculotropin antineoplastic agent indole alkaloid rhynchophylline antineoplastic activity apoptosis Article cell cycle assay cell invasion assay cell migration cell proliferation cell signaling controlled study down regulation enzyme activation enzyme phosphorylation genetic transfection human human cell liver cell carcinoma MTT assay protein binding protein expression signal transduction TUNEL assay Uncaria Western blotting wound healing assay apoptosis cell motion chemistry drug effects Hep-G2 cell line liver cell carcinoma liver tumor metabolism metastasis pathology signal transduction tumor cell line Antineoplastic Agents, Phytogenic Apoptosis Carcinoma, Hepatocellular Cell Line, Tumor Cell Movement Cell Proliferation Hep G2 Cells Humans Indole Alkaloids Liver Neoplasms Neoplasm Metastasis Signal Transduction Uncaria Lee, H Baek, S.H Lee, J.H Kim, C Ko, J.-H Lee, S.-G Chinnathambi, A Alharbi, S.A Yang, W.M Um, J.-Y Sethi, G Ahn, K.S Isorhynchophylline, a potent plant alkaloid, induces apoptotic and anti-metastatic effects in human hepatocellular carcinoma cells through the modulation of diverse cell signaling cascades
description	10.3390/ijms18051095
author2	PHARMACOLOGY
author_facet	PHARMACOLOGY Lee, H Baek, S.H Lee, J.H Kim, C Ko, J.-H Lee, S.-G Chinnathambi, A Alharbi, S.A Yang, W.M Um, J.-Y Sethi, G Ahn, K.S
format	Article
author	Lee, H Baek, S.H Lee, J.H Kim, C Ko, J.-H Lee, S.-G Chinnathambi, A Alharbi, S.A Yang, W.M Um, J.-Y Sethi, G Ahn, K.S
author_sort	Lee, H
title	Isorhynchophylline, a potent plant alkaloid, induces apoptotic and anti-metastatic effects in human hepatocellular carcinoma cells through the modulation of diverse cell signaling cascades
title_short	Isorhynchophylline, a potent plant alkaloid, induces apoptotic and anti-metastatic effects in human hepatocellular carcinoma cells through the modulation of diverse cell signaling cascades
title_full	Isorhynchophylline, a potent plant alkaloid, induces apoptotic and anti-metastatic effects in human hepatocellular carcinoma cells through the modulation of diverse cell signaling cascades
title_fullStr	Isorhynchophylline, a potent plant alkaloid, induces apoptotic and anti-metastatic effects in human hepatocellular carcinoma cells through the modulation of diverse cell signaling cascades
title_full_unstemmed	Isorhynchophylline, a potent plant alkaloid, induces apoptotic and anti-metastatic effects in human hepatocellular carcinoma cells through the modulation of diverse cell signaling cascades
title_sort	isorhynchophylline, a potent plant alkaloid, induces apoptotic and anti-metastatic effects in human hepatocellular carcinoma cells through the modulation of diverse cell signaling cascades
publisher	MDPI
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/183525
_version_	1821189475995222016

Isorhynchophylline, a potent plant alkaloid, induces apoptotic and anti-metastatic effects in human hepatocellular carcinoma cells through the modulation of diverse cell signaling cascades

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