Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis

• Main Authors: Mencarelli A., Khameneh H.J., Fric J., Vacca M., El Daker S., Janela B., Tang J.P., Nabti S., Balachander A., Lim T.S., Ginhoux F., Ricciardi-Castagnoli P., Mortellaro A.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: calcineurin; CD11b antigen; CD4 antigen; cre recombinase; dectin 1; glycoprotein p 15095; interleukin 10; interleukin 12; interleukin 12p40; interleukin 17; interleukin 2; interleukin 23; interleukin 6; major histocompatibility antigen class 2; myeloperoxidase; transcription factor FOXP3; transcription factor NFAT; transcription factor Nfat1; transcription factor Nfat2; transforming growth factor beta; unclassified drug; antigen; cation; cell; digestive system; gene expression; homeostasis; immune system; microorganism; pathogen; pathology; protein; rodent; tolerance; animal cell; animal experiment; animal model; animal tissue; Article; bone marrow cell; cell expansion; cell population; colitis; controlled study; disease association; enteritis; immunological tolerance; mouse; nonhuman; protein expression; regulatory T lymphocyte; signal transduction; Th1 cell; Th17 cell; animal; C57BL mouse; female; gene; genetics; human; immunology; intestine; knockout mouse; male; Mus; Animals; Calcineurin; CD11c Antigen; Colitis; Female; Genes, MHC Class II; Homeostasis; Humans; Interleukin-2; Intestines; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cells; Th1 Cells; Th17 Cells
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174235
• Institution: National University of Singapore

10.1038/s41467-018-03495-3