Knockdown of POLA2 increases gemcitabine resistance in lung cancer cells

• Main Authors: Koh, V, Kwan, H.Y, Tan, W.L, Mah, T.L, Yong, W.P
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: BioMed Central Ltd. 2020
• Subjects: DNA directed DNA polymerase alpha; gemcitabine; small interfering RNA; antineoplastic antimetabolite; deoxycytidine; DNA directed DNA polymerase beta; Article; cancer resistance; cell viability; chemosensitivity; concentration response; controlled study; drug effect; gene function; gene silencing; genetic association; genetic conservation; genetic transfection; H1299 cell line; H1650 cell line; human; human cell; lung cancer cell line; non small cell lung cancer; PC9 cell line; POLA2 gene; sequence analysis; single nucleotide polymorphism; wild type; analogs and derivatives; biology; chromosomal mapping; drug resistance; epistasis; gene expression regulation; genetics; lung tumor; procedures; tumor cell line; Antimetabolites, Antineoplastic; Cell Line, Tumor; Chromosome Mapping; Computational Biology; Deoxycytidine; DNA Polymerase I; Drug Resistance, Neoplasm; Epistasis, Genetic; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Lung Neoplasms; Polymorphism, Single Nucleotide
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174242
• Institution: National University of Singapore

10.1186/s12864-016-3322-x