Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1

• Main Authors: Fujita, K, Mao, Y, Uchida, S, Chen, X, Shiwaku, H, Tamura, T, Ito, H, Watase, K, Homma, H, Tagawa, K, Sudol, M, Okazawa, H
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: ataxin 1; retinoid related orphan receptor alpha; transcription factor; transcription factor YAPdeltaC; unclassified drug; Atxn1 protein, mouse; isoprotein; phosphoprotein; Rora protein, mouse; signal transducing adaptor protein; Yap protein, mouse; adult; cells and cell components; developmental biology; gene expression; mutation; numerical model; pathology; adulthood; animal cell; animal experiment; animal model; animal tissue; Article; controlled study; functional disease; genetic transcription; in vivo study; male; mouse; nonhuman; protein domain; protein expression; protein protein interaction; spinocerebellar degeneration; supplementation; animal; cerebellum; cytology; disease model; gene expression regulation; gene knock-in; genetics; metabolism; nerve cell; pathophysiology; phenotype; rotarod test; Mus; Adaptor Proteins, Signal Transducing; Animals; Ataxin-1; Cerebellum; Disease Models, Animal; Gene Expression Regulation, Developmental; Gene Knock-In Techniques; Male; Mice; Neurons; Nuclear Receptor Subfamily 1, Group F, Member 1; Phenotype; Phosphoproteins; Protein Isoforms; Rotarod Performance Test; Spinocerebellar Ataxias
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174376
• Institution: National University of Singapore

10.1038/s41467-017-01790-z