Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility

10.1038/s41467-017-00837-5

Saved in:

Bibliographic Details
Main Authors:	Chintalapudi, S.R, Maria, D, Di Wang, X, Bailey, J.N.C, Allingham, R, Brilliant, M, Budenz, D, Fingert, J, Gaasterland, D, Gaasterland, T, Haines, J.L, Hark, L, Hauser, M, Igo, R, Hee Kang, J, Kraft, P, Lee, R, Lichter, P, Liu, Y, Moroi, S, Pasquale, L.R, Pericak-Vance, M, Realini, A, Rhee, D, Richards, J.R, Ritch, R, Schuman, J, Scott, W.K, Singh, K, Sit, A, Vollrath, D, Wollstein, G, Zack, D, Aung, T, Bonnemaijer, P, Cheng, C.-Y, Craig, J, Van Duijn, C, Gharahkhani, P, Iglesias Gonzalez, A, Hammond, C.J, Hewitt, A, Hoehn, R, Jonansson, F, Khawaja, A, Chuen Khor, C, Klaver, C.C.W, Lotery, A, MacKey, D, MacGregor, S, Pang, C, Pasutto, F, Stefansson, K, Thorleifsson, G, Thorsteinsdottir, U, Vitart, V, Vithana, E, Young, T, Zeller, T, Hysi, P.G, Wiggs, J.L, Williams, R.W, Jablonski, M.M
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	cacna2d1 protein pregabalin protein unclassified drug CACNA2D1 protein, human CACNA2D1 protein, mouse calcium channel chemical binding genetic analysis genetic variation nervous system disorder polymerase chain reaction polymorphism risk factor aged animal experiment animal model animal tissue Article case report cellular distribution clinical article controlled study drug protein binding female genetic association genetic susceptibility genetic variability genome-wide association study glaucoma haplotype human human tissue intraocular pressure male mouse nonhuman open angle glaucoma protein function quantitative trait locus single nucleotide polymorphism animal C57BL mouse cohort analysis DBA mouse disease model genetic predisposition genetics metabolism pathophysiology Mus Aged Animals Calcium Channels Cohort Studies Disease Models, Animal Female Genetic Predisposition to Disease Genome-Wide Association Study Glaucoma, Open-Angle Humans Intraocular Pressure Male Mice Mice, Inbred C57BL Mice, Inbred DBA Polymorphism, Single Nucleotide
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174380
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	National University of Singapore

id	sg-nus-scholar.10635-174380
record_format	dspace
spelling	sg-nus-scholar.10635-1743802024-04-12T05:49:07Z Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility Chintalapudi, S.R Maria, D Di Wang, X Bailey, J.N.C Allingham, R Brilliant, M Budenz, D Fingert, J Gaasterland, D Gaasterland, T Haines, J.L Hark, L Hauser, M Igo, R Hee Kang, J Kraft, P Lee, R Lichter, P Liu, Y Moroi, S Pasquale, L.R Pericak-Vance, M Realini, A Rhee, D Richards, J.R Ritch, R Schuman, J Scott, W.K Singh, K Sit, A Vollrath, D Wollstein, G Zack, D Aung, T Bonnemaijer, P Cheng, C.-Y Craig, J Van Duijn, C Gharahkhani, P Iglesias Gonzalez, A Hammond, C.J Hewitt, A Hoehn, R Jonansson, F Khawaja, A Chuen Khor, C Klaver, C.C.W Lotery, A MacKey, D MacGregor, S Pang, C Pasutto, F Stefansson, K Thorleifsson, G Thorsteinsdottir, U Vitart, V Vithana, E Young, T Zeller, T Hysi, P.G Wiggs, J.L Williams, R.W Jablonski, M.M DUKE-NUS MEDICAL SCHOOL OPHTHALMOLOGY DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) cacna2d1 protein pregabalin protein unclassified drug CACNA2D1 protein, human CACNA2D1 protein, mouse calcium channel chemical binding genetic analysis genetic variation nervous system disorder polymerase chain reaction polymorphism protein risk factor aged animal experiment animal model animal tissue Article case report cellular distribution clinical article controlled study drug protein binding female genetic association genetic susceptibility genetic variability genetic variation genome-wide association study glaucoma haplotype human human tissue intraocular pressure male mouse nonhuman open angle glaucoma protein function quantitative trait locus single nucleotide polymorphism animal C57BL mouse cohort analysis DBA mouse disease model genetic predisposition genetics metabolism pathophysiology Mus Aged Animals Calcium Channels Cohort Studies Disease Models, Animal Female Genetic Predisposition to Disease Genome-Wide Association Study Glaucoma, Open-Angle Humans Intraocular Pressure Male Mice Mice, Inbred C57BL Mice, Inbred DBA Polymorphism, Single Nucleotide 10.1038/s41467-017-00837-5 Nature Communications 8 1 1755 2020-09-04T02:28:32Z 2020-09-04T02:28:32Z 2017 Article Chintalapudi, S.R, Maria, D, Di Wang, X, Bailey, J.N.C, Allingham, R, Brilliant, M, Budenz, D, Fingert, J, Gaasterland, D, Gaasterland, T, Haines, J.L, Hark, L, Hauser, M, Igo, R, Hee Kang, J, Kraft, P, Lee, R, Lichter, P, Liu, Y, Moroi, S, Pasquale, L.R, Pericak-Vance, M, Realini, A, Rhee, D, Richards, J.R, Ritch, R, Schuman, J, Scott, W.K, Singh, K, Sit, A, Vollrath, D, Wollstein, G, Zack, D, Aung, T, Bonnemaijer, P, Cheng, C.-Y, Craig, J, Van Duijn, C, Gharahkhani, P, Iglesias Gonzalez, A, Hammond, C.J, Hewitt, A, Hoehn, R, Jonansson, F, Khawaja, A, Chuen Khor, C, Klaver, C.C.W, Lotery, A, MacKey, D, MacGregor, S, Pang, C, Pasutto, F, Stefansson, K, Thorleifsson, G, Thorsteinsdottir, U, Vitart, V, Vithana, E, Young, T, Zeller, T, Hysi, P.G, Wiggs, J.L, Williams, R.W, Jablonski, M.M (2017). Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility. Nature Communications 8 (1) : 1755. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-017-00837-5 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/174380 Nature Publishing Group Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	cacna2d1 protein pregabalin protein unclassified drug CACNA2D1 protein, human CACNA2D1 protein, mouse calcium channel chemical binding genetic analysis genetic variation nervous system disorder polymerase chain reaction polymorphism protein risk factor aged animal experiment animal model animal tissue Article case report cellular distribution clinical article controlled study drug protein binding female genetic association genetic susceptibility genetic variability genetic variation genome-wide association study glaucoma haplotype human human tissue intraocular pressure male mouse nonhuman open angle glaucoma protein function quantitative trait locus single nucleotide polymorphism animal C57BL mouse cohort analysis DBA mouse disease model genetic predisposition genetics metabolism pathophysiology Mus Aged Animals Calcium Channels Cohort Studies Disease Models, Animal Female Genetic Predisposition to Disease Genome-Wide Association Study Glaucoma, Open-Angle Humans Intraocular Pressure Male Mice Mice, Inbred C57BL Mice, Inbred DBA Polymorphism, Single Nucleotide
spellingShingle	cacna2d1 protein pregabalin protein unclassified drug CACNA2D1 protein, human CACNA2D1 protein, mouse calcium channel chemical binding genetic analysis genetic variation nervous system disorder polymerase chain reaction polymorphism protein risk factor aged animal experiment animal model animal tissue Article case report cellular distribution clinical article controlled study drug protein binding female genetic association genetic susceptibility genetic variability genetic variation genome-wide association study glaucoma haplotype human human tissue intraocular pressure male mouse nonhuman open angle glaucoma protein function quantitative trait locus single nucleotide polymorphism animal C57BL mouse cohort analysis DBA mouse disease model genetic predisposition genetics metabolism pathophysiology Mus Aged Animals Calcium Channels Cohort Studies Disease Models, Animal Female Genetic Predisposition to Disease Genome-Wide Association Study Glaucoma, Open-Angle Humans Intraocular Pressure Male Mice Mice, Inbred C57BL Mice, Inbred DBA Polymorphism, Single Nucleotide Chintalapudi, S.R Maria, D Di Wang, X Bailey, J.N.C Allingham, R Brilliant, M Budenz, D Fingert, J Gaasterland, D Gaasterland, T Haines, J.L Hark, L Hauser, M Igo, R Hee Kang, J Kraft, P Lee, R Lichter, P Liu, Y Moroi, S Pasquale, L.R Pericak-Vance, M Realini, A Rhee, D Richards, J.R Ritch, R Schuman, J Scott, W.K Singh, K Sit, A Vollrath, D Wollstein, G Zack, D Aung, T Bonnemaijer, P Cheng, C.-Y Craig, J Van Duijn, C Gharahkhani, P Iglesias Gonzalez, A Hammond, C.J Hewitt, A Hoehn, R Jonansson, F Khawaja, A Chuen Khor, C Klaver, C.C.W Lotery, A MacKey, D MacGregor, S Pang, C Pasutto, F Stefansson, K Thorleifsson, G Thorsteinsdottir, U Vitart, V Vithana, E Young, T Zeller, T Hysi, P.G Wiggs, J.L Williams, R.W Jablonski, M.M Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility
description	10.1038/s41467-017-00837-5
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Chintalapudi, S.R Maria, D Di Wang, X Bailey, J.N.C Allingham, R Brilliant, M Budenz, D Fingert, J Gaasterland, D Gaasterland, T Haines, J.L Hark, L Hauser, M Igo, R Hee Kang, J Kraft, P Lee, R Lichter, P Liu, Y Moroi, S Pasquale, L.R Pericak-Vance, M Realini, A Rhee, D Richards, J.R Ritch, R Schuman, J Scott, W.K Singh, K Sit, A Vollrath, D Wollstein, G Zack, D Aung, T Bonnemaijer, P Cheng, C.-Y Craig, J Van Duijn, C Gharahkhani, P Iglesias Gonzalez, A Hammond, C.J Hewitt, A Hoehn, R Jonansson, F Khawaja, A Chuen Khor, C Klaver, C.C.W Lotery, A MacKey, D MacGregor, S Pang, C Pasutto, F Stefansson, K Thorleifsson, G Thorsteinsdottir, U Vitart, V Vithana, E Young, T Zeller, T Hysi, P.G Wiggs, J.L Williams, R.W Jablonski, M.M
format	Article
author	Chintalapudi, S.R Maria, D Di Wang, X Bailey, J.N.C Allingham, R Brilliant, M Budenz, D Fingert, J Gaasterland, D Gaasterland, T Haines, J.L Hark, L Hauser, M Igo, R Hee Kang, J Kraft, P Lee, R Lichter, P Liu, Y Moroi, S Pasquale, L.R Pericak-Vance, M Realini, A Rhee, D Richards, J.R Ritch, R Schuman, J Scott, W.K Singh, K Sit, A Vollrath, D Wollstein, G Zack, D Aung, T Bonnemaijer, P Cheng, C.-Y Craig, J Van Duijn, C Gharahkhani, P Iglesias Gonzalez, A Hammond, C.J Hewitt, A Hoehn, R Jonansson, F Khawaja, A Chuen Khor, C Klaver, C.C.W Lotery, A MacKey, D MacGregor, S Pang, C Pasutto, F Stefansson, K Thorleifsson, G Thorsteinsdottir, U Vitart, V Vithana, E Young, T Zeller, T Hysi, P.G Wiggs, J.L Williams, R.W Jablonski, M.M
author_sort	Chintalapudi, S.R
title	Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility
title_short	Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility
title_full	Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility
title_fullStr	Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility
title_full_unstemmed	Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility
title_sort	systems genetics identifies a role for cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174380
_version_	1800914236325494784

Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility

Similar Items