Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility

Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility

10.1038/s41467-017-00837-5

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Bibliographic Details
Main Authors:	Chintalapudi, S.R, Maria, D, Di Wang, X, Bailey, J.N.C, Allingham, R, Brilliant, M, Budenz, D, Fingert, J, Gaasterland, D, Gaasterland, T, Haines, J.L, Hark, L, Hauser, M, Igo, R, Hee Kang, J, Kraft, P, Lee, R, Lichter, P, Liu, Y, Moroi, S, Pasquale, L.R, Pericak-Vance, M, Realini, A, Rhee, D, Richards, J.R, Ritch, R, Schuman, J, Scott, W.K, Singh, K, Sit, A, Vollrath, D, Wollstein, G, Zack, D, Aung, T, Bonnemaijer, P, Cheng, C.-Y, Craig, J, Van Duijn, C, Gharahkhani, P, Iglesias Gonzalez, A, Hammond, C.J, Hewitt, A, Hoehn, R, Jonansson, F, Khawaja, A, Chuen Khor, C, Klaver, C.C.W, Lotery, A, MacKey, D, MacGregor, S, Pang, C, Pasutto, F, Stefansson, K, Thorleifsson, G, Thorsteinsdottir, U, Vitart, V, Vithana, E, Young, T, Zeller, T, Hysi, P.G, Wiggs, J.L, Williams, R.W, Jablonski, M.M
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	cacna2d1 protein pregabalin protein unclassified drug CACNA2D1 protein, human CACNA2D1 protein, mouse calcium channel chemical binding genetic analysis genetic variation nervous system disorder polymerase chain reaction polymorphism risk factor aged animal experiment animal model animal tissue Article case report cellular distribution clinical article controlled study drug protein binding female genetic association genetic susceptibility genetic variability genome-wide association study glaucoma haplotype human human tissue intraocular pressure male mouse nonhuman open angle glaucoma protein function quantitative trait locus single nucleotide polymorphism animal C57BL mouse cohort analysis DBA mouse disease model genetic predisposition genetics metabolism pathophysiology Mus Aged Animals Calcium Channels Cohort Studies Disease Models, Animal Female Genetic Predisposition to Disease Genome-Wide Association Study Glaucoma, Open-Angle Humans Intraocular Pressure Male Mice Mice, Inbred C57BL Mice, Inbred DBA Polymorphism, Single Nucleotide
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174380
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Institution:	National University of Singapore

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