Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility

• Main Authors: Chintalapudi, S.R, Maria, D, Di Wang, X, Bailey, J.N.C, Allingham, R, Brilliant, M, Budenz, D, Fingert, J, Gaasterland, D, Gaasterland, T, Haines, J.L, Hark, L, Hauser, M, Igo, R, Hee Kang, J, Kraft, P, Lee, R, Lichter, P, Liu, Y, Moroi, S, Pasquale, L.R, Pericak-Vance, M, Realini, A, Rhee, D, Richards, J.R, Ritch, R, Schuman, J, Scott, W.K, Singh, K, Sit, A, Vollrath, D, Wollstein, G, Zack, D, Aung, T, Bonnemaijer, P, Cheng, C.-Y, Craig, J, Van Duijn, C, Gharahkhani, P, Iglesias Gonzalez, A, Hammond, C.J, Hewitt, A, Hoehn, R, Jonansson, F, Khawaja, A, Chuen Khor, C, Klaver, C.C.W, Lotery, A, MacKey, D, MacGregor, S, Pang, C, Pasutto, F, Stefansson, K, Thorleifsson, G, Thorsteinsdottir, U, Vitart, V, Vithana, E, Young, T, Zeller, T, Hysi, P.G, Wiggs, J.L, Williams, R.W, Jablonski, M.M
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: cacna2d1 protein; pregabalin; protein; unclassified drug; CACNA2D1 protein, human; CACNA2D1 protein, mouse; calcium channel; chemical binding; genetic analysis; genetic variation; nervous system disorder; polymerase chain reaction; polymorphism; risk factor; aged; animal experiment; animal model; animal tissue; Article; case report; cellular distribution; clinical article; controlled study; drug protein binding; female; genetic association; genetic susceptibility; genetic variability; genome-wide association study; glaucoma; haplotype; human; human tissue; intraocular pressure; male; mouse; nonhuman; open angle glaucoma; protein function; quantitative trait locus; single nucleotide polymorphism; animal; C57BL mouse; cohort analysis; DBA mouse; disease model; genetic predisposition; genetics; metabolism; pathophysiology; Mus; Aged; Animals; Calcium Channels; Cohort Studies; Disease Models, Animal; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Polymorphism, Single Nucleotide
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174380
• Institution: National University of Singapore

10.1038/s41467-017-00837-5