NOTUM is a potential pharmacodynamic biomarker of wnt pathway inhibition

• Main Authors: Madan, B, Ke, Z, Lei, Z.D, Oliver, F.A, Oshima, M, Lee, M.A, Rozen, S, Virshup, D.M
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Impact Journals LLC 2020
• Subjects: AXIN2 protein; biological marker; esterase; Notum protein; unclassified drug; acyltransferase; axin; AXIN2 protein, human; ETC-159; fused heterocyclic rings; membrane protein; Notum protein, human; PORCN protein, human; tumor marker; animal experiment; animal model; Article; autocrine effect; blood analysis; controlled study; in vitro study; in vivo study; intracellular signaling; mouse; nonhuman; prediction; protein determination; protein expression; protein secretion; Wnt signaling pathway; animal; antagonists and inhibitors; Bagg albino mouse; biosynthesis; C57BL mouse; down regulation; drug effects; fibrosarcoma; genetic transfection; human; metabolism; nude mouse; pancreas tumor; tumor cell line; Wnt signaling; xenograft; Acyltransferases; Animals; Axin Protein; Biomarkers, Tumor; Cell Line, Tumor; Down-Regulation; Esterases; Fibrosarcoma; Heterocyclic Compounds, 4 or More Rings; Heterografts; Humans; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Pancreatic Neoplasms; Transfection; Wnt Signaling Pathway
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174984
• Institution: National University of Singapore

10.18632/oncotarget.7157