NOTUM is a potential pharmacodynamic biomarker of wnt pathway inhibition

10.18632/oncotarget.7157

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Main Authors:	Madan, B, Ke, Z, Lei, Z.D, Oliver, F.A, Oshima, M, Lee, M.A, Rozen, S, Virshup, D.M
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Impact Journals LLC 2020
Subjects:	AXIN2 protein biological marker esterase Notum protein unclassified drug acyltransferase axin AXIN2 protein, human ETC-159 fused heterocyclic rings membrane protein Notum protein, human PORCN protein, human tumor marker animal experiment animal model Article autocrine effect blood analysis controlled study in vitro study in vivo study intracellular signaling mouse nonhuman prediction protein determination protein expression protein secretion Wnt signaling pathway animal antagonists and inhibitors Bagg albino mouse biosynthesis C57BL mouse down regulation drug effects fibrosarcoma genetic transfection human metabolism nude mouse pancreas tumor tumor cell line Wnt signaling xenograft Acyltransferases Animals Axin Protein Biomarkers, Tumor Cell Line, Tumor Down-Regulation Esterases Fibrosarcoma Heterocyclic Compounds, 4 or More Rings Heterografts Humans Membrane Proteins Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Pancreatic Neoplasms Transfection Wnt Signaling Pathway
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174984
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1749842023-09-13T21:41:56Z NOTUM is a potential pharmacodynamic biomarker of wnt pathway inhibition Madan, B Ke, Z Lei, Z.D Oliver, F.A Oshima, M Lee, M.A Rozen, S Virshup, D.M DUKE-NUS MEDICAL SCHOOL AXIN2 protein biological marker esterase Notum protein unclassified drug acyltransferase axin AXIN2 protein, human esterase ETC-159 fused heterocyclic rings membrane protein Notum protein, human PORCN protein, human tumor marker animal experiment animal model Article autocrine effect blood analysis controlled study in vitro study in vivo study intracellular signaling mouse nonhuman prediction protein determination protein expression protein secretion Wnt signaling pathway animal antagonists and inhibitors Bagg albino mouse biosynthesis C57BL mouse down regulation drug effects fibrosarcoma genetic transfection human metabolism nude mouse pancreas tumor tumor cell line Wnt signaling xenograft Acyltransferases Animals Axin Protein Biomarkers, Tumor Cell Line, Tumor Down-Regulation Esterases Fibrosarcoma Heterocyclic Compounds, 4 or More Rings Heterografts Humans Membrane Proteins Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Pancreatic Neoplasms Transfection Wnt Signaling Pathway 10.18632/oncotarget.7157 Oncotarget 7 11 12386-12392 2020-09-09T01:40:00Z 2020-09-09T01:40:00Z 2016 Article Madan, B, Ke, Z, Lei, Z.D, Oliver, F.A, Oshima, M, Lee, M.A, Rozen, S, Virshup, D.M (2016). NOTUM is a potential pharmacodynamic biomarker of wnt pathway inhibition. Oncotarget 7 (11) : 12386-12392. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.7157 19492553 https://scholarbank.nus.edu.sg/handle/10635/174984 Impact Journals LLC Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	AXIN2 protein biological marker esterase Notum protein unclassified drug acyltransferase axin AXIN2 protein, human esterase ETC-159 fused heterocyclic rings membrane protein Notum protein, human PORCN protein, human tumor marker animal experiment animal model Article autocrine effect blood analysis controlled study in vitro study in vivo study intracellular signaling mouse nonhuman prediction protein determination protein expression protein secretion Wnt signaling pathway animal antagonists and inhibitors Bagg albino mouse biosynthesis C57BL mouse down regulation drug effects fibrosarcoma genetic transfection human metabolism nude mouse pancreas tumor tumor cell line Wnt signaling xenograft Acyltransferases Animals Axin Protein Biomarkers, Tumor Cell Line, Tumor Down-Regulation Esterases Fibrosarcoma Heterocyclic Compounds, 4 or More Rings Heterografts Humans Membrane Proteins Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Pancreatic Neoplasms Transfection Wnt Signaling Pathway
spellingShingle	AXIN2 protein biological marker esterase Notum protein unclassified drug acyltransferase axin AXIN2 protein, human esterase ETC-159 fused heterocyclic rings membrane protein Notum protein, human PORCN protein, human tumor marker animal experiment animal model Article autocrine effect blood analysis controlled study in vitro study in vivo study intracellular signaling mouse nonhuman prediction protein determination protein expression protein secretion Wnt signaling pathway animal antagonists and inhibitors Bagg albino mouse biosynthesis C57BL mouse down regulation drug effects fibrosarcoma genetic transfection human metabolism nude mouse pancreas tumor tumor cell line Wnt signaling xenograft Acyltransferases Animals Axin Protein Biomarkers, Tumor Cell Line, Tumor Down-Regulation Esterases Fibrosarcoma Heterocyclic Compounds, 4 or More Rings Heterografts Humans Membrane Proteins Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Pancreatic Neoplasms Transfection Wnt Signaling Pathway Madan, B Ke, Z Lei, Z.D Oliver, F.A Oshima, M Lee, M.A Rozen, S Virshup, D.M NOTUM is a potential pharmacodynamic biomarker of wnt pathway inhibition
description	10.18632/oncotarget.7157
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Madan, B Ke, Z Lei, Z.D Oliver, F.A Oshima, M Lee, M.A Rozen, S Virshup, D.M
format	Article
author	Madan, B Ke, Z Lei, Z.D Oliver, F.A Oshima, M Lee, M.A Rozen, S Virshup, D.M
author_sort	Madan, B
title	NOTUM is a potential pharmacodynamic biomarker of wnt pathway inhibition
title_short	NOTUM is a potential pharmacodynamic biomarker of wnt pathway inhibition
title_full	NOTUM is a potential pharmacodynamic biomarker of wnt pathway inhibition
title_fullStr	NOTUM is a potential pharmacodynamic biomarker of wnt pathway inhibition
title_full_unstemmed	NOTUM is a potential pharmacodynamic biomarker of wnt pathway inhibition
title_sort	notum is a potential pharmacodynamic biomarker of wnt pathway inhibition
publisher	Impact Journals LLC
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174984
_version_	1778169825845051392

NOTUM is a potential pharmacodynamic biomarker of wnt pathway inhibition

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