Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models

• Main Authors: Hwang, I.Y, Koh, E, Wong, A, March, J.C, Bentley, W.E, Lee, Y.S, Chang, M.W
• Other Authors: BIOCHEMISTRY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: alanine racemase; probiotic agent; bacterium; biofilm; enzyme activity; genetic engineering; infectivity; nematode; pathogen; probiotics; rodent; virulence; animal experiment; animal model; animal tissue; Article; bacterial strain; Caenorhabditis elegans; controlled study; drug efficacy; Escherichia coli; Escherichia coli Nissle 1917; female; in vivo study; infection prevention; intestine infection; mouse; nonhuman; Pseudomonas infection; treatment outcome; animal; disease model; gastroenteritis; genetics; Institute for Cancer Research mouse; microbiology; pathogenicity; procedures; Pseudomonas aeruginosa; transgenic microorganism; Animalia; Bacteria (microorganisms); Mus; Animals; Disease Models, Animal; Female; Gastroenteritis; Genetic Engineering; Mice; Mice, Inbred ICR; Microorganisms, Genetically-Modified; Probiotics; Pseudomonas Infections; Virulence
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174427
• Institution: National University of Singapore

10.1038/ncomms15028