Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality

10.1038/s41467-017-02287-5

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Main Authors:	Kitagawa M., Liao P.-J., Lee K.H., Wong J., Shang S.C., Minami N., Sampetrean O., Saya H., Lingyun D., Prabhu N., Diam G.K., Sobota R., Larsson A., Nordlund P., McCormick F., Ghosh S., Epstein D.M., Dymock B.W., Lee S.H.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	a131 antineoplastic agent mammalian target of rapamycin mitogen activated protein kinase phosphatidylinositol 3 kinase phosphatidylinositol 5 phosphate 2 kinase phosphatidylinositol kinase phosphotransferase inhibitor protein kinase B Ras protein unclassified drug membrane protein phosphotransferase PIK3IP1 protein, human protein kinase inhibitor cancer cells and cell components enzyme enzyme activity growth inhibition lipid animal experiment animal model animal tissue antineoplastic activity Article breast cancer cancer cell centrosome controlled study enzyme activation female human human cell intracellular signaling lethality mitosis mouse nonhuman upregulation animal antagonists and inhibitors Bagg albino mouse cell proliferation cell survival drug effect drug screening metabolism neoplasm nude mouse signal transduction tumor cell line Animals Cell Line, Tumor Cell Proliferation Cell Survival Female Humans Membrane Proteins Mice Mice, Inbred BALB C Mice, Nude Mitosis Neoplasms Phosphotransferases (Alcohol Group Acceptor) Protein Kinase Inhibitors ras Proteins Signal Transduction Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174480
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1744802024-04-05T09:03:57Z Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality Kitagawa M. Liao P.-J. Lee K.H. Wong J. Shang S.C. Minami N. Sampetrean O. Saya H. Lingyun D. Prabhu N. Diam G.K. Sobota R. Larsson A. Nordlund P. McCormick F. Ghosh S. Epstein D.M. Dymock B.W. Lee S.H. DUKE-NUS MEDICAL SCHOOL CANCER SCIENCE INSTITUTE OF SINGAPORE PHARMACY a131 antineoplastic agent mammalian target of rapamycin mitogen activated protein kinase phosphatidylinositol 3 kinase phosphatidylinositol 5 phosphate 2 kinase phosphatidylinositol kinase phosphotransferase inhibitor protein kinase B Ras protein unclassified drug membrane protein phosphotransferase PIK3IP1 protein, human protein kinase inhibitor Ras protein cancer cells and cell components enzyme enzyme activity growth inhibition lipid animal experiment animal model animal tissue antineoplastic activity Article breast cancer cancer cell centrosome controlled study enzyme activation female human human cell intracellular signaling lethality mitosis mouse nonhuman upregulation animal antagonists and inhibitors Bagg albino mouse cell proliferation cell survival drug effect drug screening metabolism mitosis neoplasm nude mouse signal transduction tumor cell line Animals Cell Line, Tumor Cell Proliferation Cell Survival Female Humans Membrane Proteins Mice Mice, Inbred BALB C Mice, Nude Mitosis Neoplasms Phosphotransferases (Alcohol Group Acceptor) Protein Kinase Inhibitors ras Proteins Signal Transduction Xenograft Model Antitumor Assays 10.1038/s41467-017-02287-5 Nature Communications 8 1 2200 2020-09-06T16:02:58Z 2020-09-06T16:02:58Z 2017 Article Kitagawa M., Liao P.-J., Lee K.H., Wong J., Shang S.C., Minami N., Sampetrean O., Saya H., Lingyun D., Prabhu N., Diam G.K., Sobota R., Larsson A., Nordlund P., McCormick F., Ghosh S., Epstein D.M., Dymock B.W., Lee S.H. (2017). Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality. Nature Communications 8 (1) : 2200. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-017-02287-5 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/174480 Nature Publishing Group Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	a131 antineoplastic agent mammalian target of rapamycin mitogen activated protein kinase phosphatidylinositol 3 kinase phosphatidylinositol 5 phosphate 2 kinase phosphatidylinositol kinase phosphotransferase inhibitor protein kinase B Ras protein unclassified drug membrane protein phosphotransferase PIK3IP1 protein, human protein kinase inhibitor Ras protein cancer cells and cell components enzyme enzyme activity growth inhibition lipid animal experiment animal model animal tissue antineoplastic activity Article breast cancer cancer cell centrosome controlled study enzyme activation female human human cell intracellular signaling lethality mitosis mouse nonhuman upregulation animal antagonists and inhibitors Bagg albino mouse cell proliferation cell survival drug effect drug screening metabolism mitosis neoplasm nude mouse signal transduction tumor cell line Animals Cell Line, Tumor Cell Proliferation Cell Survival Female Humans Membrane Proteins Mice Mice, Inbred BALB C Mice, Nude Mitosis Neoplasms Phosphotransferases (Alcohol Group Acceptor) Protein Kinase Inhibitors ras Proteins Signal Transduction Xenograft Model Antitumor Assays
spellingShingle	a131 antineoplastic agent mammalian target of rapamycin mitogen activated protein kinase phosphatidylinositol 3 kinase phosphatidylinositol 5 phosphate 2 kinase phosphatidylinositol kinase phosphotransferase inhibitor protein kinase B Ras protein unclassified drug membrane protein phosphotransferase PIK3IP1 protein, human protein kinase inhibitor Ras protein cancer cells and cell components enzyme enzyme activity growth inhibition lipid animal experiment animal model animal tissue antineoplastic activity Article breast cancer cancer cell centrosome controlled study enzyme activation female human human cell intracellular signaling lethality mitosis mouse nonhuman upregulation animal antagonists and inhibitors Bagg albino mouse cell proliferation cell survival drug effect drug screening metabolism mitosis neoplasm nude mouse signal transduction tumor cell line Animals Cell Line, Tumor Cell Proliferation Cell Survival Female Humans Membrane Proteins Mice Mice, Inbred BALB C Mice, Nude Mitosis Neoplasms Phosphotransferases (Alcohol Group Acceptor) Protein Kinase Inhibitors ras Proteins Signal Transduction Xenograft Model Antitumor Assays Kitagawa M. Liao P.-J. Lee K.H. Wong J. Shang S.C. Minami N. Sampetrean O. Saya H. Lingyun D. Prabhu N. Diam G.K. Sobota R. Larsson A. Nordlund P. McCormick F. Ghosh S. Epstein D.M. Dymock B.W. Lee S.H. Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
description	10.1038/s41467-017-02287-5
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Kitagawa M. Liao P.-J. Lee K.H. Wong J. Shang S.C. Minami N. Sampetrean O. Saya H. Lingyun D. Prabhu N. Diam G.K. Sobota R. Larsson A. Nordlund P. McCormick F. Ghosh S. Epstein D.M. Dymock B.W. Lee S.H.
format	Article
author	Kitagawa M. Liao P.-J. Lee K.H. Wong J. Shang S.C. Minami N. Sampetrean O. Saya H. Lingyun D. Prabhu N. Diam G.K. Sobota R. Larsson A. Nordlund P. McCormick F. Ghosh S. Epstein D.M. Dymock B.W. Lee S.H.
author_sort	Kitagawa M.
title	Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
title_short	Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
title_full	Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
title_fullStr	Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
title_full_unstemmed	Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
title_sort	dual blockade of the lipid kinase pip4ks and mitotic pathways leads to cancer-selective lethality
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174480
_version_	1800914247598735360

Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality

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