Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality

• Main Authors: Kitagawa M., Liao P.-J., Lee K.H., Wong J., Shang S.C., Minami N., Sampetrean O., Saya H., Lingyun D., Prabhu N., Diam G.K., Sobota R., Larsson A., Nordlund P., McCormick F., Ghosh S., Epstein D.M., Dymock B.W., Lee S.H.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: a131; antineoplastic agent; mammalian target of rapamycin; mitogen activated protein kinase; phosphatidylinositol 3 kinase; phosphatidylinositol 5 phosphate 2 kinase; phosphatidylinositol kinase; phosphotransferase inhibitor; protein kinase B; Ras protein; unclassified drug; membrane protein; phosphotransferase; PIK3IP1 protein, human; protein kinase inhibitor; cancer; cells and cell components; enzyme; enzyme activity; growth; inhibition; lipid; animal experiment; animal model; animal tissue; antineoplastic activity; Article; breast cancer; cancer cell; centrosome; controlled study; enzyme activation; female; human; human cell; intracellular signaling; lethality; mitosis; mouse; nonhuman; upregulation; animal; antagonists and inhibitors; Bagg albino mouse; cell proliferation; cell survival; drug effect; drug screening; metabolism; neoplasm; nude mouse; signal transduction; tumor cell line; Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female; Humans; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Mitosis; Neoplasms; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; ras Proteins; Signal Transduction; Xenograft Model Antitumor Assays
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174480
• Institution: National University of Singapore

10.1038/s41467-017-02287-5