Inhibition of IRE1?-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia

• Main Authors: Sun, H, Lin, D.-C, Guo, X, Masouleh, B.K, Gery, S, Cao, Q, Alkan, S, Ikezoe, T, Akiba, C, Paquette, R, Chien, W, Müller-Tidow, C, Jing, Y, Agelopoulos, K, Müschen, M, Koeffler, H.P
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: Impact Journals LLC 2020
• Subjects: 2 hydroxy 1 naphthaldehyde; arsenic trioxide; bortezomib; caspase; cyclin D1; enzyme inhibitor; inositol requiring enzyme 1; microRNA 34a; mitogen activated protein kinase; mkc 3946; phosphatidylinositol 3 kinase; protein bcl 2; protein p21; protein p27; protein serine threonine kinase; ribonuclease inhibitor; stf 083010; stress activated protein kinase; toyocamycin; unclassified drug; X box binding protein 1; ERN1 protein, human; messenger RNA; microRNA; protein kinase inhibitor; ribonuclease; XBP1 protein, human; Xbp1 protein, mouse; acute myeloblastic leukemia; animal cell; antiproliferative activity; apoptosis; Article; cancer inhibition; clinical article; concentration response; controlled study; drug cytotoxicity; drug potency; enzyme induction; enzyme inhibition; G1 phase cell cycle checkpoint; gene; gene expression regulation; gene function; gene targeting; human; human cell; in vitro study; IRE1alpha gene; mouse; myeloid leukemia cell line; nonhuman; protein expression; RNA splicing; unfolded protein response; upregulation; XBP1 gene; animal; antagonists and inhibitors; enzymology; genetic transfection; genetics; Leukemia, Myeloid, Acute; metabolism; pathology; signal transduction; Animals; Endoribonucleases; Humans; Mice; MicroRNAs; Protein Kinase Inhibitors; Protein-Serine-Threonine Kinases; Ribonucleases; RNA, Messenger; Signal Transduction; Transfection; Unfolded Protein Response; Up-Regulation; X-Box Binding Protein 1
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180395
• Institution: National University of Singapore

10.18632/oncotarget.7702