Inhibition of IRE1?-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia

10.18632/oncotarget.7702

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Main Authors:	Sun, H, Lin, D.-C, Guo, X, Masouleh, B.K, Gery, S, Cao, Q, Alkan, S, Ikezoe, T, Akiba, C, Paquette, R, Chien, W, Müller-Tidow, C, Jing, Y, Agelopoulos, K, Müschen, M, Koeffler, H.P
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	Impact Journals LLC 2020
Subjects:	2 hydroxy 1 naphthaldehyde arsenic trioxide bortezomib caspase cyclin D1 enzyme inhibitor inositol requiring enzyme 1 microRNA 34a mitogen activated protein kinase mkc 3946 phosphatidylinositol 3 kinase protein bcl 2 protein p21 protein p27 protein serine threonine kinase ribonuclease inhibitor stf 083010 stress activated protein kinase toyocamycin unclassified drug X box binding protein 1 ERN1 protein, human messenger RNA microRNA protein kinase inhibitor ribonuclease XBP1 protein, human Xbp1 protein, mouse acute myeloblastic leukemia animal cell antiproliferative activity apoptosis Article cancer inhibition clinical article concentration response controlled study drug cytotoxicity drug potency enzyme induction enzyme inhibition G1 phase cell cycle checkpoint gene gene expression regulation gene function gene targeting human human cell in vitro study IRE1alpha gene mouse myeloid leukemia cell line nonhuman protein expression RNA splicing unfolded protein response upregulation XBP1 gene animal antagonists and inhibitors enzymology genetic transfection genetics Leukemia, Myeloid, Acute metabolism pathology signal transduction Animals Endoribonucleases Humans Mice MicroRNAs Protein Kinase Inhibitors Protein-Serine-Threonine Kinases Ribonucleases RNA, Messenger Signal Transduction Transfection Unfolded Protein Response Up-Regulation X-Box Binding Protein 1
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/180395
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1803952024-04-18T03:09:38Z Inhibition of IRE1?-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia Sun, H Lin, D.-C Guo, X Masouleh, B.K Gery, S Cao, Q Alkan, S Ikezoe, T Akiba, C Paquette, R Chien, W Müller-Tidow, C Jing, Y Agelopoulos, K Müschen, M Koeffler, H.P CANCER SCIENCE INSTITUTE OF SINGAPORE MEDICINE 2 hydroxy 1 naphthaldehyde arsenic trioxide bortezomib caspase cyclin D1 enzyme inhibitor inositol requiring enzyme 1 microRNA 34a mitogen activated protein kinase mkc 3946 phosphatidylinositol 3 kinase protein bcl 2 protein p21 protein p27 protein serine threonine kinase ribonuclease inhibitor stf 083010 stress activated protein kinase toyocamycin unclassified drug X box binding protein 1 ERN1 protein, human messenger RNA microRNA protein kinase inhibitor protein serine threonine kinase ribonuclease X box binding protein 1 XBP1 protein, human Xbp1 protein, mouse acute myeloblastic leukemia animal cell antiproliferative activity apoptosis Article cancer inhibition clinical article concentration response controlled study drug cytotoxicity drug potency enzyme induction enzyme inhibition G1 phase cell cycle checkpoint gene gene expression regulation gene function gene targeting human human cell in vitro study IRE1alpha gene mouse myeloid leukemia cell line nonhuman protein expression RNA splicing unfolded protein response upregulation XBP1 gene animal antagonists and inhibitors enzymology genetic transfection genetics Leukemia, Myeloid, Acute metabolism pathology signal transduction Animals Endoribonucleases Humans Leukemia, Myeloid, Acute Mice MicroRNAs Protein Kinase Inhibitors Protein-Serine-Threonine Kinases Ribonucleases RNA, Messenger Signal Transduction Transfection Unfolded Protein Response Up-Regulation X-Box Binding Protein 1 10.18632/oncotarget.7702 Oncotarget 7 14 18736-18749 2020-10-26T08:47:31Z 2020-10-26T08:47:31Z 2016 Article Sun, H, Lin, D.-C, Guo, X, Masouleh, B.K, Gery, S, Cao, Q, Alkan, S, Ikezoe, T, Akiba, C, Paquette, R, Chien, W, Müller-Tidow, C, Jing, Y, Agelopoulos, K, Müschen, M, Koeffler, H.P (2016). Inhibition of IRE1?-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia. Oncotarget 7 (14) : 18736-18749. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.7702 1949-2553 https://scholarbank.nus.edu.sg/handle/10635/180395 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Impact Journals LLC Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	2 hydroxy 1 naphthaldehyde arsenic trioxide bortezomib caspase cyclin D1 enzyme inhibitor inositol requiring enzyme 1 microRNA 34a mitogen activated protein kinase mkc 3946 phosphatidylinositol 3 kinase protein bcl 2 protein p21 protein p27 protein serine threonine kinase ribonuclease inhibitor stf 083010 stress activated protein kinase toyocamycin unclassified drug X box binding protein 1 ERN1 protein, human messenger RNA microRNA protein kinase inhibitor protein serine threonine kinase ribonuclease X box binding protein 1 XBP1 protein, human Xbp1 protein, mouse acute myeloblastic leukemia animal cell antiproliferative activity apoptosis Article cancer inhibition clinical article concentration response controlled study drug cytotoxicity drug potency enzyme induction enzyme inhibition G1 phase cell cycle checkpoint gene gene expression regulation gene function gene targeting human human cell in vitro study IRE1alpha gene mouse myeloid leukemia cell line nonhuman protein expression RNA splicing unfolded protein response upregulation XBP1 gene animal antagonists and inhibitors enzymology genetic transfection genetics Leukemia, Myeloid, Acute metabolism pathology signal transduction Animals Endoribonucleases Humans Leukemia, Myeloid, Acute Mice MicroRNAs Protein Kinase Inhibitors Protein-Serine-Threonine Kinases Ribonucleases RNA, Messenger Signal Transduction Transfection Unfolded Protein Response Up-Regulation X-Box Binding Protein 1
spellingShingle	2 hydroxy 1 naphthaldehyde arsenic trioxide bortezomib caspase cyclin D1 enzyme inhibitor inositol requiring enzyme 1 microRNA 34a mitogen activated protein kinase mkc 3946 phosphatidylinositol 3 kinase protein bcl 2 protein p21 protein p27 protein serine threonine kinase ribonuclease inhibitor stf 083010 stress activated protein kinase toyocamycin unclassified drug X box binding protein 1 ERN1 protein, human messenger RNA microRNA protein kinase inhibitor protein serine threonine kinase ribonuclease X box binding protein 1 XBP1 protein, human Xbp1 protein, mouse acute myeloblastic leukemia animal cell antiproliferative activity apoptosis Article cancer inhibition clinical article concentration response controlled study drug cytotoxicity drug potency enzyme induction enzyme inhibition G1 phase cell cycle checkpoint gene gene expression regulation gene function gene targeting human human cell in vitro study IRE1alpha gene mouse myeloid leukemia cell line nonhuman protein expression RNA splicing unfolded protein response upregulation XBP1 gene animal antagonists and inhibitors enzymology genetic transfection genetics Leukemia, Myeloid, Acute metabolism pathology signal transduction Animals Endoribonucleases Humans Leukemia, Myeloid, Acute Mice MicroRNAs Protein Kinase Inhibitors Protein-Serine-Threonine Kinases Ribonucleases RNA, Messenger Signal Transduction Transfection Unfolded Protein Response Up-Regulation X-Box Binding Protein 1 Sun, H Lin, D.-C Guo, X Masouleh, B.K Gery, S Cao, Q Alkan, S Ikezoe, T Akiba, C Paquette, R Chien, W Müller-Tidow, C Jing, Y Agelopoulos, K Müschen, M Koeffler, H.P Inhibition of IRE1?-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia
description	10.18632/oncotarget.7702
author2	CANCER SCIENCE INSTITUTE OF SINGAPORE
author_facet	CANCER SCIENCE INSTITUTE OF SINGAPORE Sun, H Lin, D.-C Guo, X Masouleh, B.K Gery, S Cao, Q Alkan, S Ikezoe, T Akiba, C Paquette, R Chien, W Müller-Tidow, C Jing, Y Agelopoulos, K Müschen, M Koeffler, H.P
format	Article
author	Sun, H Lin, D.-C Guo, X Masouleh, B.K Gery, S Cao, Q Alkan, S Ikezoe, T Akiba, C Paquette, R Chien, W Müller-Tidow, C Jing, Y Agelopoulos, K Müschen, M Koeffler, H.P
author_sort	Sun, H
title	Inhibition of IRE1?-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia
title_short	Inhibition of IRE1?-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia
title_full	Inhibition of IRE1?-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia
title_fullStr	Inhibition of IRE1?-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia
title_full_unstemmed	Inhibition of IRE1?-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia
title_sort	inhibition of ire1?-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia
publisher	Impact Journals LLC
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/180395
_version_	1800914590901469184

Inhibition of IRE1?-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia

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