The prostaglandin H2 analog U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways

• Main Authors: Su, L., Kong, X., Lim, S., Loo, S., Tan, S., Poh, K., Dutton, J., Stewart, C., Cook, S., Su, X., Ma, J., Zhang, J., Ye, L.
• Other Authors: MEDICINE
• Format: Article
• Published: BioMed Central Ltd. 2020
• Subjects: 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid; 6 [[2 [[4 (2,4 dichlorophenyl) 5 (4 methyl 1h imidazol 2 yl) 2 pyrimidinyl]amino]ethyl]amino]nicotinonitrile; mitogen activated protein kinase p38; pyridine derivative; pyrimidine derivative; animal; cell differentiation; cell line; cytology; disease model; drug effect; endothelium cell; enzyme activation; enzymology; hindlimb; human; induced pluripotent stem cell; ischemia; MAPK signaling; mesoderm; metabolism; nonobese diabetic mouse; pathology; perfusion; SCID mouse; vascularization; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Cell Differentiation; Cell Line; Disease Models, Animal; Endothelial Cells; Enzyme Activation; Hindlimb; Humans; Induced Pluripotent Stem Cells; Ischemia; MAP Kinase Signaling System; Mesoderm; Mice, Inbred NOD; Mice, SCID; p38 Mitogen-Activated Protein Kinases; Perfusion; Pyridines; Pyrimidines
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174517
• Institution: National University of Singapore

10.1186/s13287-018-1061-4