Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer

• Main Authors: Tang Y.C., Ho S.-C., Tan E., Ng A.W.T., McPherson J.R., Goh G.Y.L., Teh B.T., Bard F., Rozen S.G.
• Other Authors: BIOCHEMISTRY
• Format: Article
• Published: 2020
• Subjects: phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; protein kinase LKB1; short hairpin RNA; small interfering RNA; NUAK1 protein, human; protein kinase; protein serine threonine kinase; PTEN protein, human; repressor protein; STK11 protein, human; tumor protein; ADAMTS20 gene; AP1M2 gene; Article; breast cancer; breast cancer cell line; breast epithelium cell; cell viability; cohort analysis; controlled study; drug sensitivity; enzyme inhibition; female; functional genomics; gene; gene activity; gene mutation; HMMR gene; human; human cell; NUAK1 gene; PIK3CB gene; RNA interference; STK11 gene; breast tumor; deficiency; gene expression regulation; genetics; genomics; human genome; lethal mutation; mammary gland; metabolism; pathology; procedures; tumor cell line; Breast Neoplasms; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Genome, Human; Genomics; Humans; Mammary Glands, Human; Neoplasm Proteins; Protein Kinases; Protein-Serine-Threonine Kinases; PTEN Phosphohydrolase; Repressor Proteins; RNA, Small Interfering; Synthetic Lethal Mutations
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174603
• Institution: National University of Singapore

10.1186/s13058-018-0949-3