Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer

Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer

10.1186/s13058-018-0949-3

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Bibliographic Details
Main Authors:	Tang Y.C., Ho S.-C., Tan E., Ng A.W.T., McPherson J.R., Goh G.Y.L., Teh B.T., Bard F., Rozen S.G.
Other Authors:	BIOCHEMISTRY
Format:	Article
Published:	2020
Subjects:	phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase protein kinase LKB1 short hairpin RNA small interfering RNA NUAK1 protein, human protein kinase protein serine threonine kinase PTEN protein, human repressor protein STK11 protein, human tumor protein ADAMTS20 gene AP1M2 gene Article breast cancer breast cancer cell line breast epithelium cell cell viability cohort analysis controlled study drug sensitivity enzyme inhibition female functional genomics gene gene activity gene mutation HMMR gene human human cell NUAK1 gene PIK3CB gene RNA interference STK11 gene breast tumor deficiency gene expression regulation genetics genomics human genome lethal mutation mammary gland metabolism pathology procedures tumor cell line Breast Neoplasms Cell Line, Tumor Female Gene Expression Regulation, Neoplastic Genome, Human Genomics Humans Mammary Glands, Human Neoplasm Proteins Protein Kinases Protein-Serine-Threonine Kinases PTEN Phosphohydrolase Repressor Proteins RNA, Small Interfering Synthetic Lethal Mutations
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174603
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Institution:	National University of Singapore

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