Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer

10.1186/s13058-018-0949-3

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Main Authors:	Tang Y.C., Ho S.-C., Tan E., Ng A.W.T., McPherson J.R., Goh G.Y.L., Teh B.T., Bard F., Rozen S.G.
Other Authors:	BIOCHEMISTRY
Format:	Article
Published:	2020
Subjects:	phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase protein kinase LKB1 short hairpin RNA small interfering RNA NUAK1 protein, human protein kinase protein serine threonine kinase PTEN protein, human repressor protein STK11 protein, human tumor protein ADAMTS20 gene AP1M2 gene Article breast cancer breast cancer cell line breast epithelium cell cell viability cohort analysis controlled study drug sensitivity enzyme inhibition female functional genomics gene gene activity gene mutation HMMR gene human human cell NUAK1 gene PIK3CB gene RNA interference STK11 gene breast tumor deficiency gene expression regulation genetics genomics human genome lethal mutation mammary gland metabolism pathology procedures tumor cell line Breast Neoplasms Cell Line, Tumor Female Gene Expression Regulation, Neoplastic Genome, Human Genomics Humans Mammary Glands, Human Neoplasm Proteins Protein Kinases Protein-Serine-Threonine Kinases PTEN Phosphohydrolase Repressor Proteins RNA, Small Interfering Synthetic Lethal Mutations
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174603
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1746032024-04-22T03:17:23Z Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer Tang Y.C. Ho S.-C. Tan E. Ng A.W.T. McPherson J.R. Goh G.Y.L. Teh B.T. Bard F. Rozen S.G. BIOCHEMISTRY DUKE-NUS MEDICAL SCHOOL phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase protein kinase LKB1 short hairpin RNA small interfering RNA NUAK1 protein, human phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase protein kinase protein serine threonine kinase PTEN protein, human repressor protein small interfering RNA STK11 protein, human tumor protein ADAMTS20 gene AP1M2 gene Article breast cancer breast cancer cell line breast epithelium cell cell viability cohort analysis controlled study drug sensitivity enzyme inhibition female functional genomics gene gene activity gene mutation HMMR gene human human cell NUAK1 gene PIK3CB gene RNA interference STK11 gene breast tumor deficiency gene expression regulation genetics genomics human genome lethal mutation mammary gland metabolism pathology procedures tumor cell line Breast Neoplasms Cell Line, Tumor Female Gene Expression Regulation, Neoplastic Genome, Human Genomics Humans Mammary Glands, Human Neoplasm Proteins Protein Kinases Protein-Serine-Threonine Kinases PTEN Phosphohydrolase Repressor Proteins RNA, Small Interfering Synthetic Lethal Mutations 10.1186/s13058-018-0949-3 Breast Cancer Research 20 1 22 2020-09-08T03:24:01Z 2020-09-08T03:24:01Z 2018 Article Tang Y.C., Ho S.-C., Tan E., Ng A.W.T., McPherson J.R., Goh G.Y.L., Teh B.T., Bard F., Rozen S.G. (2018). Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer. Breast Cancer Research 20 (1) : 22. ScholarBank@NUS Repository. https://doi.org/10.1186/s13058-018-0949-3 1465-5411 https://scholarbank.nus.edu.sg/handle/10635/174603 Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase protein kinase LKB1 short hairpin RNA small interfering RNA NUAK1 protein, human phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase protein kinase protein serine threonine kinase PTEN protein, human repressor protein small interfering RNA STK11 protein, human tumor protein ADAMTS20 gene AP1M2 gene Article breast cancer breast cancer cell line breast epithelium cell cell viability cohort analysis controlled study drug sensitivity enzyme inhibition female functional genomics gene gene activity gene mutation HMMR gene human human cell NUAK1 gene PIK3CB gene RNA interference STK11 gene breast tumor deficiency gene expression regulation genetics genomics human genome lethal mutation mammary gland metabolism pathology procedures tumor cell line Breast Neoplasms Cell Line, Tumor Female Gene Expression Regulation, Neoplastic Genome, Human Genomics Humans Mammary Glands, Human Neoplasm Proteins Protein Kinases Protein-Serine-Threonine Kinases PTEN Phosphohydrolase Repressor Proteins RNA, Small Interfering Synthetic Lethal Mutations
spellingShingle	phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase protein kinase LKB1 short hairpin RNA small interfering RNA NUAK1 protein, human phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase protein kinase protein serine threonine kinase PTEN protein, human repressor protein small interfering RNA STK11 protein, human tumor protein ADAMTS20 gene AP1M2 gene Article breast cancer breast cancer cell line breast epithelium cell cell viability cohort analysis controlled study drug sensitivity enzyme inhibition female functional genomics gene gene activity gene mutation HMMR gene human human cell NUAK1 gene PIK3CB gene RNA interference STK11 gene breast tumor deficiency gene expression regulation genetics genomics human genome lethal mutation mammary gland metabolism pathology procedures tumor cell line Breast Neoplasms Cell Line, Tumor Female Gene Expression Regulation, Neoplastic Genome, Human Genomics Humans Mammary Glands, Human Neoplasm Proteins Protein Kinases Protein-Serine-Threonine Kinases PTEN Phosphohydrolase Repressor Proteins RNA, Small Interfering Synthetic Lethal Mutations Tang Y.C. Ho S.-C. Tan E. Ng A.W.T. McPherson J.R. Goh G.Y.L. Teh B.T. Bard F. Rozen S.G. Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer
description	10.1186/s13058-018-0949-3
author2	BIOCHEMISTRY
author_facet	BIOCHEMISTRY Tang Y.C. Ho S.-C. Tan E. Ng A.W.T. McPherson J.R. Goh G.Y.L. Teh B.T. Bard F. Rozen S.G.
format	Article
author	Tang Y.C. Ho S.-C. Tan E. Ng A.W.T. McPherson J.R. Goh G.Y.L. Teh B.T. Bard F. Rozen S.G.
author_sort	Tang Y.C.
title	Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer
title_short	Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer
title_full	Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer
title_fullStr	Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer
title_full_unstemmed	Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer
title_sort	functional genomics identifies specific vulnerabilities in pten-deficient breast cancer
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174603
_version_	1800914260892581888

Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer

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