Localized delivery of pilocarpine to hypofunctional salivary glands through electrospun nanofiber mats: An ex vivo and in vivo study

• Main Authors: Muthumariappan S., Ng W.C., Adine C., Ng K.K., Davoodi P., Wang C.-H., Ferreira J.N.
• Other Authors: BIOMEDICAL ENGINEERING
• Format: Article
• Published: 2020
• Subjects: caspase 3; electrospun nanofiber; Ki 67 antigen; macrogol; nanofiber; pilocarpine; polyglactin; unclassified drug; biomaterial; apoptosis; Article; biocompatibility; biological activity; cell proliferation; cytotoxicity; drug formulation; drug release; electrospinning; encapsulation; ex vivo study; immunofluorescence; in vivo study; nonhuman; protein degradation; protein expression; salivary gland; scanning electron microscopy; xerostomia; animal; C57BL mouse; cell compartmentalization; cell death; chemistry; drug delivery system; drug effect; female; Institute for Cancer Research mouse; intradermal drug administration; metabolism; pathophysiology; saliva; treatment outcome; ultrastructure; Animals; Biocompatible Materials; Cell Compartmentation; Cell Death; Drug Delivery Systems; Drug Liberation; Female; Injections, Intradermal; Ki-67 Antigen; Mice, Inbred C57BL; Mice, Inbred ICR; Nanofibers; Pilocarpine; Saliva; Salivary Glands; Treatment Outcome
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174659
• Institution: National University of Singapore

10.3390/ijms20030541