Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses

10.1038/ncomms12143

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Main Authors:	Kapeli, K, Pratt, G.A, Vu, A.Q, Hutt, K.R, Martinez, F.J, Sundararaman, B, Batra, R, Freese, P, Lambert, N.J, Huelga, S.C, Chun, S.J, Liang, T.Y, Chang, J, Donohue, J.P, Shiue, L, Zhang, J, Zhu, H, Cambi, F, Kasarskis, E, Hoon, S, Ares, M, Burge, C.B, Ravits, J, Rigo, F, Yeo, G.W
Other Authors:	PHYSIOLOGY
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	fused in sarcoma protein messenger RNA protein TAF15 RNA RNA binding protein TAR DNA binding protein unclassified drug antisense oligonucleotide DNA binding protein FUS protein, human FUS protein, mouse RNA binding protein FUS small interfering RNA TAF15 protein, human TAF15 protein, mouse TATA binding protein associated factor TDP-43 protein, human TDP-43 protein, mouse brain chemical binding genetic engineering genetic marker mutation nervous system disorder protein rodent 3' untranslated region 5' untranslated region adult alternative RNA splicing amyotrophic lateral sclerosis animal cell animal tissue Article case report controlled study down regulation female gene expression gene expression regulation gene mutation genetic variability human intron motoneuron mouse neural stem cell nonhuman nucleotide motif nucleotide sequence protein RNA binding RNA metabolism RNA stability turnover time animal biology C57BL mouse disease model fibroblast gene knockdown genetics high throughput sequencing induced pluripotent stem cell metabolism primary cell culture procedures sequence analysis 3' Untranslated Regions Alternative Splicing Amyotrophic Lateral Sclerosis Animals Computational Biology Disease Models, Animal DNA-Binding Proteins Female Fibroblasts Gene Knockdown Techniques High-Throughput Nucleotide Sequencing Humans Induced Pluripotent Stem Cells Introns Mice Mice, Inbred C57BL Motor Neurons Mutation Oligonucleotides, Antisense Primary Cell Culture RNA, Messenger RNA, Small Interfering RNA-Binding Protein FUS Sequence Analysis, RNA TATA-Binding Protein Associated Factors
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174950
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spelling	sg-nus-scholar.10635-1749502024-04-04T01:11:38Z Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses Kapeli, K Pratt, G.A Vu, A.Q Hutt, K.R Martinez, F.J Sundararaman, B Batra, R Freese, P Lambert, N.J Huelga, S.C Chun, S.J Liang, T.Y Chang, J Donohue, J.P Shiue, L Zhang, J Zhu, H Cambi, F Kasarskis, E Hoon, S Ares, M Burge, C.B Ravits, J Rigo, F Yeo, G.W PHYSIOLOGY fused in sarcoma protein messenger RNA protein TAF15 RNA RNA binding protein TAR DNA binding protein unclassified drug antisense oligonucleotide DNA binding protein FUS protein, human FUS protein, mouse messenger RNA RNA binding protein FUS small interfering RNA TAF15 protein, human TAF15 protein, mouse TATA binding protein associated factor TDP-43 protein, human TDP-43 protein, mouse brain chemical binding genetic engineering genetic marker mutation nervous system disorder protein RNA rodent 3' untranslated region 5' untranslated region adult alternative RNA splicing amyotrophic lateral sclerosis animal cell animal tissue Article case report controlled study down regulation female gene expression gene expression regulation gene mutation genetic variability human intron motoneuron mouse neural stem cell nonhuman nucleotide motif nucleotide sequence protein RNA binding RNA metabolism RNA stability turnover time amyotrophic lateral sclerosis animal biology C57BL mouse disease model fibroblast gene knockdown genetics high throughput sequencing induced pluripotent stem cell metabolism mutation primary cell culture procedures sequence analysis 3' Untranslated Regions Alternative Splicing Amyotrophic Lateral Sclerosis Animals Computational Biology Disease Models, Animal DNA-Binding Proteins Female Fibroblasts Gene Knockdown Techniques High-Throughput Nucleotide Sequencing Humans Induced Pluripotent Stem Cells Introns Mice Mice, Inbred C57BL Motor Neurons Mutation Oligonucleotides, Antisense Primary Cell Culture RNA, Messenger RNA, Small Interfering RNA-Binding Protein FUS Sequence Analysis, RNA TATA-Binding Protein Associated Factors 10.1038/ncomms12143 Nature Communications 7 12143 2020-09-09T01:31:20Z 2020-09-09T01:31:20Z 2016 Article Kapeli, K, Pratt, G.A, Vu, A.Q, Hutt, K.R, Martinez, F.J, Sundararaman, B, Batra, R, Freese, P, Lambert, N.J, Huelga, S.C, Chun, S.J, Liang, T.Y, Chang, J, Donohue, J.P, Shiue, L, Zhang, J, Zhu, H, Cambi, F, Kasarskis, E, Hoon, S, Ares, M, Burge, C.B, Ravits, J, Rigo, F, Yeo, G.W (2016). Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses. Nature Communications 7 : 12143. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms12143 20411723 https://scholarbank.nus.edu.sg/handle/10635/174950 Nature Publishing Group Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	fused in sarcoma protein messenger RNA protein TAF15 RNA RNA binding protein TAR DNA binding protein unclassified drug antisense oligonucleotide DNA binding protein FUS protein, human FUS protein, mouse messenger RNA RNA binding protein FUS small interfering RNA TAF15 protein, human TAF15 protein, mouse TATA binding protein associated factor TDP-43 protein, human TDP-43 protein, mouse brain chemical binding genetic engineering genetic marker mutation nervous system disorder protein RNA rodent 3' untranslated region 5' untranslated region adult alternative RNA splicing amyotrophic lateral sclerosis animal cell animal tissue Article case report controlled study down regulation female gene expression gene expression regulation gene mutation genetic variability human intron motoneuron mouse neural stem cell nonhuman nucleotide motif nucleotide sequence protein RNA binding RNA metabolism RNA stability turnover time amyotrophic lateral sclerosis animal biology C57BL mouse disease model fibroblast gene knockdown genetics high throughput sequencing induced pluripotent stem cell metabolism mutation primary cell culture procedures sequence analysis 3' Untranslated Regions Alternative Splicing Amyotrophic Lateral Sclerosis Animals Computational Biology Disease Models, Animal DNA-Binding Proteins Female Fibroblasts Gene Knockdown Techniques High-Throughput Nucleotide Sequencing Humans Induced Pluripotent Stem Cells Introns Mice Mice, Inbred C57BL Motor Neurons Mutation Oligonucleotides, Antisense Primary Cell Culture RNA, Messenger RNA, Small Interfering RNA-Binding Protein FUS Sequence Analysis, RNA TATA-Binding Protein Associated Factors
spellingShingle	fused in sarcoma protein messenger RNA protein TAF15 RNA RNA binding protein TAR DNA binding protein unclassified drug antisense oligonucleotide DNA binding protein FUS protein, human FUS protein, mouse messenger RNA RNA binding protein FUS small interfering RNA TAF15 protein, human TAF15 protein, mouse TATA binding protein associated factor TDP-43 protein, human TDP-43 protein, mouse brain chemical binding genetic engineering genetic marker mutation nervous system disorder protein RNA rodent 3' untranslated region 5' untranslated region adult alternative RNA splicing amyotrophic lateral sclerosis animal cell animal tissue Article case report controlled study down regulation female gene expression gene expression regulation gene mutation genetic variability human intron motoneuron mouse neural stem cell nonhuman nucleotide motif nucleotide sequence protein RNA binding RNA metabolism RNA stability turnover time amyotrophic lateral sclerosis animal biology C57BL mouse disease model fibroblast gene knockdown genetics high throughput sequencing induced pluripotent stem cell metabolism mutation primary cell culture procedures sequence analysis 3' Untranslated Regions Alternative Splicing Amyotrophic Lateral Sclerosis Animals Computational Biology Disease Models, Animal DNA-Binding Proteins Female Fibroblasts Gene Knockdown Techniques High-Throughput Nucleotide Sequencing Humans Induced Pluripotent Stem Cells Introns Mice Mice, Inbred C57BL Motor Neurons Mutation Oligonucleotides, Antisense Primary Cell Culture RNA, Messenger RNA, Small Interfering RNA-Binding Protein FUS Sequence Analysis, RNA TATA-Binding Protein Associated Factors Kapeli, K Pratt, G.A Vu, A.Q Hutt, K.R Martinez, F.J Sundararaman, B Batra, R Freese, P Lambert, N.J Huelga, S.C Chun, S.J Liang, T.Y Chang, J Donohue, J.P Shiue, L Zhang, J Zhu, H Cambi, F Kasarskis, E Hoon, S Ares, M Burge, C.B Ravits, J Rigo, F Yeo, G.W Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
description	10.1038/ncomms12143
author2	PHYSIOLOGY
author_facet	PHYSIOLOGY Kapeli, K Pratt, G.A Vu, A.Q Hutt, K.R Martinez, F.J Sundararaman, B Batra, R Freese, P Lambert, N.J Huelga, S.C Chun, S.J Liang, T.Y Chang, J Donohue, J.P Shiue, L Zhang, J Zhu, H Cambi, F Kasarskis, E Hoon, S Ares, M Burge, C.B Ravits, J Rigo, F Yeo, G.W
format	Article
author	Kapeli, K Pratt, G.A Vu, A.Q Hutt, K.R Martinez, F.J Sundararaman, B Batra, R Freese, P Lambert, N.J Huelga, S.C Chun, S.J Liang, T.Y Chang, J Donohue, J.P Shiue, L Zhang, J Zhu, H Cambi, F Kasarskis, E Hoon, S Ares, M Burge, C.B Ravits, J Rigo, F Yeo, G.W
author_sort	Kapeli, K
title	Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
title_short	Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
title_full	Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
title_fullStr	Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
title_full_unstemmed	Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
title_sort	distinct and shared functions of als-associated proteins tdp-43, fus and taf15 revealed by multisystem analyses
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174950
_version_	1795374360765136896

Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses

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