Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses

Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses

10.1038/ncomms12143

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Bibliographic Details
Main Authors:	Kapeli, K, Pratt, G.A, Vu, A.Q, Hutt, K.R, Martinez, F.J, Sundararaman, B, Batra, R, Freese, P, Lambert, N.J, Huelga, S.C, Chun, S.J, Liang, T.Y, Chang, J, Donohue, J.P, Shiue, L, Zhang, J, Zhu, H, Cambi, F, Kasarskis, E, Hoon, S, Ares, M, Burge, C.B, Ravits, J, Rigo, F, Yeo, G.W
Other Authors:	PHYSIOLOGY
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	fused in sarcoma protein messenger RNA protein TAF15 RNA RNA binding protein TAR DNA binding protein unclassified drug antisense oligonucleotide DNA binding protein FUS protein, human FUS protein, mouse RNA binding protein FUS small interfering RNA TAF15 protein, human TAF15 protein, mouse TATA binding protein associated factor TDP-43 protein, human TDP-43 protein, mouse brain chemical binding genetic engineering genetic marker mutation nervous system disorder protein rodent 3' untranslated region 5' untranslated region adult alternative RNA splicing amyotrophic lateral sclerosis animal cell animal tissue Article case report controlled study down regulation female gene expression gene expression regulation gene mutation genetic variability human intron motoneuron mouse neural stem cell nonhuman nucleotide motif nucleotide sequence protein RNA binding RNA metabolism RNA stability turnover time animal biology C57BL mouse disease model fibroblast gene knockdown genetics high throughput sequencing induced pluripotent stem cell metabolism primary cell culture procedures sequence analysis 3' Untranslated Regions Alternative Splicing Amyotrophic Lateral Sclerosis Animals Computational Biology Disease Models, Animal DNA-Binding Proteins Female Fibroblasts Gene Knockdown Techniques High-Throughput Nucleotide Sequencing Humans Induced Pluripotent Stem Cells Introns Mice Mice, Inbred C57BL Motor Neurons Mutation Oligonucleotides, Antisense Primary Cell Culture RNA, Messenger RNA, Small Interfering RNA-Binding Protein FUS Sequence Analysis, RNA TATA-Binding Protein Associated Factors
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174950
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Institution:	National University of Singapore

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