N 6 -Methyladenosine: A conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5

• Main Authors: Zou, S, Toh, J.D.W, Wong, K.H.Q, Gao, Y.-G, Hong, W, Woon, E.C.Y
• Other Authors: DEPT OF BIOCHEMISTRY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: adenosine; ALKBH5 protein, human; alkylated DNA repair protein alkB homolog 5; alpha ketoglutarate dependent dioxygenase FTO; FTO protein, human; N(6)-methyladenosine; RNA; analogs and derivatives; biocatalysis; chemistry; consensus sequence; demethylation; enzyme specificity; human; metabolism; nucleotide sequence; oxidation reduction reaction; protein conformation; protein motif; RNA stability; thermodynamics; Adenosine; AlkB Homolog 5, RNA Demethylase; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Amino Acid Motifs; Base Sequence; Biocatalysis; Consensus Sequence; Demethylation; Humans; Oxidation-Reduction; Protein Conformation; RNA Stability; Substrate Specificity; Thermodynamics
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174971
• Institution: National University of Singapore

10.1038/srep25677