N 6 -Methyladenosine: A conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5

10.1038/srep25677

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Main Authors:	Zou, S, Toh, J.D.W, Wong, K.H.Q, Gao, Y.-G, Hong, W, Woon, E.C.Y
Other Authors:	BIOCHEMISTRY
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	adenosine ALKBH5 protein, human alkylated DNA repair protein alkB homolog 5 alpha ketoglutarate dependent dioxygenase FTO FTO protein, human N(6)-methyladenosine RNA analogs and derivatives biocatalysis chemistry consensus sequence demethylation enzyme specificity human metabolism nucleotide sequence oxidation reduction reaction protein conformation protein motif RNA stability thermodynamics Adenosine AlkB Homolog 5, RNA Demethylase Alpha-Ketoglutarate-Dependent Dioxygenase FTO Amino Acid Motifs Base Sequence Biocatalysis Consensus Sequence Demethylation Humans Oxidation-Reduction Protein Conformation RNA Stability Substrate Specificity Thermodynamics
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174971
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1749712024-11-11T15:32:08Z N 6 -Methyladenosine: A conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5 Zou, S Toh, J.D.W Wong, K.H.Q Gao, Y.-G Hong, W Woon, E.C.Y BIOCHEMISTRY PHARMACY adenosine ALKBH5 protein, human alkylated DNA repair protein alkB homolog 5 alpha ketoglutarate dependent dioxygenase FTO FTO protein, human N(6)-methyladenosine RNA analogs and derivatives biocatalysis chemistry consensus sequence demethylation enzyme specificity human metabolism nucleotide sequence oxidation reduction reaction protein conformation protein motif RNA stability thermodynamics Adenosine AlkB Homolog 5, RNA Demethylase Alpha-Ketoglutarate-Dependent Dioxygenase FTO Amino Acid Motifs Base Sequence Biocatalysis Consensus Sequence Demethylation Humans Oxidation-Reduction Protein Conformation RNA RNA Stability Substrate Specificity Thermodynamics 10.1038/srep25677 Scientific Reports 6 25677 2020-09-09T01:36:50Z 2020-09-09T01:36:50Z 2016 Article Zou, S, Toh, J.D.W, Wong, K.H.Q, Gao, Y.-G, Hong, W, Woon, E.C.Y (2016). N 6 -Methyladenosine: A conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5. Scientific Reports 6 : 25677. ScholarBank@NUS Repository. https://doi.org/10.1038/srep25677 20452322 https://scholarbank.nus.edu.sg/handle/10635/174971 Nature Publishing Group Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	adenosine ALKBH5 protein, human alkylated DNA repair protein alkB homolog 5 alpha ketoglutarate dependent dioxygenase FTO FTO protein, human N(6)-methyladenosine RNA analogs and derivatives biocatalysis chemistry consensus sequence demethylation enzyme specificity human metabolism nucleotide sequence oxidation reduction reaction protein conformation protein motif RNA stability thermodynamics Adenosine AlkB Homolog 5, RNA Demethylase Alpha-Ketoglutarate-Dependent Dioxygenase FTO Amino Acid Motifs Base Sequence Biocatalysis Consensus Sequence Demethylation Humans Oxidation-Reduction Protein Conformation RNA RNA Stability Substrate Specificity Thermodynamics
spellingShingle	adenosine ALKBH5 protein, human alkylated DNA repair protein alkB homolog 5 alpha ketoglutarate dependent dioxygenase FTO FTO protein, human N(6)-methyladenosine RNA analogs and derivatives biocatalysis chemistry consensus sequence demethylation enzyme specificity human metabolism nucleotide sequence oxidation reduction reaction protein conformation protein motif RNA stability thermodynamics Adenosine AlkB Homolog 5, RNA Demethylase Alpha-Ketoglutarate-Dependent Dioxygenase FTO Amino Acid Motifs Base Sequence Biocatalysis Consensus Sequence Demethylation Humans Oxidation-Reduction Protein Conformation RNA RNA Stability Substrate Specificity Thermodynamics Zou, S Toh, J.D.W Wong, K.H.Q Gao, Y.-G Hong, W Woon, E.C.Y N 6 -Methyladenosine: A conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
description	10.1038/srep25677
author2	BIOCHEMISTRY
author_facet	BIOCHEMISTRY Zou, S Toh, J.D.W Wong, K.H.Q Gao, Y.-G Hong, W Woon, E.C.Y
format	Article
author	Zou, S Toh, J.D.W Wong, K.H.Q Gao, Y.-G Hong, W Woon, E.C.Y
author_sort	Zou, S
title	N 6 -Methyladenosine: A conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
title_short	N 6 -Methyladenosine: A conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
title_full	N 6 -Methyladenosine: A conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
title_fullStr	N 6 -Methyladenosine: A conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
title_full_unstemmed	N 6 -Methyladenosine: A conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
title_sort	n 6 -methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases fto and alkbh5
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174971
_version_	1821225031502397440

N 6 -Methyladenosine: A conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5

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