New insights into the cellular temporal response to proteostatic stress

• Main Authors: Rendleman, J, Cheng, Z, Maity, S, Kastelic, N, Munschauer, M, Allgoewer, K, Teo, G, Zhang, Y.B.M, Lei, A, Parker, B, Landthaler, M, Freeberg, L, Kuersten, S, Choi, H, Vogel, C
• 其他作者: SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
• 格式: Article
• 出版: 2020
• 主題: amino acid transfer RNA ligase; chaperone; complementary DNA; DNA mismatch repair protein MSH2; integrin; messenger RNA; monocyte chemotactic protein 1; Rad51 protein; reactive oxygen metabolite; transcriptome; tunicamycin; initiation factor 2; membrane protein; PERK kinase; protein kinase R; 3' untranslated region; alternative RNA splicing; Article; bioinformatics; cellular distribution; cellular stress response; citric acid cycle; controlled study; DNA library; DNA repair; down regulation; endoplasmic reticulum stress; energy metabolism; energy yield; gene; gene expression; gene expression regulation; human; human cell; mass spectrometry; mitochondrion; oxidative phosphorylation; oxidative stress; protein binding; protein degradation; protein expression; protein footprinting; protein homeostasis; protein RNA binding; protein secondary structure; proteomics; real time polymerase chain reaction; regulatory mechanism; RNA degradation; RNA extraction; RNA sequence; RNA translation; signal transduction; upregulation; uterine cervix cancer; Western blotting; conformation; drug effect; endoplasmic reticulum; essential gene; genetic transcription; genetics; HeLa cell line; metabolism; open reading frame; physiological stress; principal component analysis; protein synthesis; ribosome; time factor; unfolded protein response; Amino Acyl-tRNA Synthetases; DNA Repair; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Gene Expression Regulation; Genes, Essential; HeLa Cells; Humans; Membrane Proteins; Nucleic Acid Conformation; Open Reading Frames; Principal Component Analysis; Protein Biosynthesis; Proteostasis; Ribosomes; Signal Transduction; Stress, Physiological; Time Factors; Transcription, Genetic; Tunicamycin; Unfolded Protein Response
• 在線閱讀: https://scholarbank.nus.edu.sg/handle/10635/175041
• 機構: National University of Singapore

10.7554/eLife.39054