Extracellular anti-angiogenic proteins augment an endosomal protein trafficking pathway to reach mitochondria and execute apoptosis in HUVECs

• Main Authors: Chen, M, Qiu, T, Wu, J, Yang, Y, Wright, G.D, Wu, M, Ge, R
• Other Authors: DEPT OF BIOLOGICAL SCIENCES
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: angiogenic protein; angiostatin; isthmin; RNA; SNARE protein; sodium proton exchange protein 1; synaptosomal associated protein 25; unclassified drug; fibronectin; heat shock protein; molecular chaperone GRP78; phosphoprotein; recombinant protein; small interfering RNA; SNAP25 protein, human; sodium proton exchange protein; sodium-hydrogen exchanger regulatory factor; thrombospondin; angiogenesis; apoptosis; Article; biochemical analysis; cell fractionation; cell interaction; cell migration; cell organelle; controlled study; cytosol; endosome; human; human cell; in vitro study; mitochondrion; priority journal; RNA interference; signal transduction; umbilical vein endothelial cell; antagonists and inhibitors; biosynthesis; cell membrane; chemistry; drug effect; endocytosis; fluorescence microscopy; fluorescence recovery after photobleaching; genetics; isolation and purification; metabolism; protein transport; Angiostatins; Apoptosis; Cell Membrane; Endocytosis; Endosomes; Fibronectins; Fluorescence Recovery After Photobleaching; Heat-Shock Proteins; Human Umbilical Vein Endothelial Cells; Humans; Microscopy, Fluorescence; Mitochondria; Neovascularization, Physiologic; Phosphoproteins; Protein Transport; Recombinant Proteins; RNA Interference; RNA, Small Interfering; Sodium-Hydrogen Exchangers; Synaptosomal-Associated Protein 25; Thrombospondins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175098
• Institution: National University of Singapore

10.1038/s41418-018-0092-9