Oncogenic RAS-induced CK1? drives nuclear FOXO proteolysis

10.1038/onc.2017.334

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Main Authors:	Zhang, F, Virshup, D.M, Cheong, J.K
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	casein kinase Ialpha caspase nuclear protein phosphatidylinositol 3 kinase proteasome protein FOXO4 protein kinase B Ras protein serine transcription factor FKHRL1 transcription factor FOXO tumor suppressor protein unclassified drug 4-(4-(2,3-dihydrobenzo(1,4)dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide benzamide derivative FOXO3 protein, human FOXO4 protein, human imidazole derivative KRAS protein, human proteasome inhibitor protein p21 small interfering RNA transcription factor apoptosis Article cancer cell line cancer growth cell mutant colon cancer human human cell nuclear export priority journal protein degradation protein expression protein induction protein phosphorylation protein processing regulatory mechanism signal transduction antagonists and inhibitors cell cycle cell nucleus drug effect genetics metabolism mutation neoplasm pathology phosphorylation tumor cell line Apoptosis Benzamides Casein Kinase Ialpha Cell Cycle Cell Line, Tumor Cell Nucleus Forkhead Box Protein O3 Humans Imidazoles Mutation Neoplasms Phosphorylation Proteasome Endopeptidase Complex Proteasome Inhibitors Protein Processing, Post-Translational Proteolysis Proto-Oncogene Proteins p21(ras) RNA, Small Interfering Serine Signal Transduction Transcription Factors
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/175130
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1751302023-08-30T22:24:30Z Oncogenic RAS-induced CK1? drives nuclear FOXO proteolysis Zhang, F Virshup, D.M Cheong, J.K DUKE-NUS MEDICAL SCHOOL casein kinase Ialpha caspase nuclear protein phosphatidylinositol 3 kinase proteasome protein FOXO4 protein kinase B Ras protein serine transcription factor FKHRL1 transcription factor FOXO tumor suppressor protein unclassified drug 4-(4-(2,3-dihydrobenzo(1,4)dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide benzamide derivative casein kinase Ialpha FOXO3 protein, human FOXO4 protein, human imidazole derivative KRAS protein, human proteasome proteasome inhibitor protein p21 serine small interfering RNA transcription factor transcription factor FKHRL1 apoptosis Article cancer cell line cancer growth cell mutant colon cancer human human cell nuclear export priority journal protein degradation protein expression protein induction protein phosphorylation protein processing regulatory mechanism signal transduction antagonists and inhibitors cell cycle cell nucleus drug effect genetics metabolism mutation neoplasm pathology phosphorylation protein degradation tumor cell line Apoptosis Benzamides Casein Kinase Ialpha Cell Cycle Cell Line, Tumor Cell Nucleus Forkhead Box Protein O3 Humans Imidazoles Mutation Neoplasms Phosphorylation Proteasome Endopeptidase Complex Proteasome Inhibitors Protein Processing, Post-Translational Proteolysis Proto-Oncogene Proteins p21(ras) RNA, Small Interfering Serine Signal Transduction Transcription Factors 10.1038/onc.2017.334 Oncogene 37 3 363-376 2020-09-09T04:12:12Z 2020-09-09T04:12:12Z 2018 Article Zhang, F, Virshup, D.M, Cheong, J.K (2018). Oncogenic RAS-induced CK1? drives nuclear FOXO proteolysis. Oncogene 37 (3) : 363-376. ScholarBank@NUS Repository. https://doi.org/10.1038/onc.2017.334 0950-9232 https://scholarbank.nus.edu.sg/handle/10635/175130 Nature Publishing Group Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	casein kinase Ialpha caspase nuclear protein phosphatidylinositol 3 kinase proteasome protein FOXO4 protein kinase B Ras protein serine transcription factor FKHRL1 transcription factor FOXO tumor suppressor protein unclassified drug 4-(4-(2,3-dihydrobenzo(1,4)dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide benzamide derivative casein kinase Ialpha FOXO3 protein, human FOXO4 protein, human imidazole derivative KRAS protein, human proteasome proteasome inhibitor protein p21 serine small interfering RNA transcription factor transcription factor FKHRL1 apoptosis Article cancer cell line cancer growth cell mutant colon cancer human human cell nuclear export priority journal protein degradation protein expression protein induction protein phosphorylation protein processing regulatory mechanism signal transduction antagonists and inhibitors cell cycle cell nucleus drug effect genetics metabolism mutation neoplasm pathology phosphorylation protein degradation tumor cell line Apoptosis Benzamides Casein Kinase Ialpha Cell Cycle Cell Line, Tumor Cell Nucleus Forkhead Box Protein O3 Humans Imidazoles Mutation Neoplasms Phosphorylation Proteasome Endopeptidase Complex Proteasome Inhibitors Protein Processing, Post-Translational Proteolysis Proto-Oncogene Proteins p21(ras) RNA, Small Interfering Serine Signal Transduction Transcription Factors
spellingShingle	casein kinase Ialpha caspase nuclear protein phosphatidylinositol 3 kinase proteasome protein FOXO4 protein kinase B Ras protein serine transcription factor FKHRL1 transcription factor FOXO tumor suppressor protein unclassified drug 4-(4-(2,3-dihydrobenzo(1,4)dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide benzamide derivative casein kinase Ialpha FOXO3 protein, human FOXO4 protein, human imidazole derivative KRAS protein, human proteasome proteasome inhibitor protein p21 serine small interfering RNA transcription factor transcription factor FKHRL1 apoptosis Article cancer cell line cancer growth cell mutant colon cancer human human cell nuclear export priority journal protein degradation protein expression protein induction protein phosphorylation protein processing regulatory mechanism signal transduction antagonists and inhibitors cell cycle cell nucleus drug effect genetics metabolism mutation neoplasm pathology phosphorylation protein degradation tumor cell line Apoptosis Benzamides Casein Kinase Ialpha Cell Cycle Cell Line, Tumor Cell Nucleus Forkhead Box Protein O3 Humans Imidazoles Mutation Neoplasms Phosphorylation Proteasome Endopeptidase Complex Proteasome Inhibitors Protein Processing, Post-Translational Proteolysis Proto-Oncogene Proteins p21(ras) RNA, Small Interfering Serine Signal Transduction Transcription Factors Zhang, F Virshup, D.M Cheong, J.K Oncogenic RAS-induced CK1? drives nuclear FOXO proteolysis
description	10.1038/onc.2017.334
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Zhang, F Virshup, D.M Cheong, J.K
format	Article
author	Zhang, F Virshup, D.M Cheong, J.K
author_sort	Zhang, F
title	Oncogenic RAS-induced CK1? drives nuclear FOXO proteolysis
title_short	Oncogenic RAS-induced CK1? drives nuclear FOXO proteolysis
title_full	Oncogenic RAS-induced CK1? drives nuclear FOXO proteolysis
title_fullStr	Oncogenic RAS-induced CK1? drives nuclear FOXO proteolysis
title_full_unstemmed	Oncogenic RAS-induced CK1? drives nuclear FOXO proteolysis
title_sort	oncogenic ras-induced ck1? drives nuclear foxo proteolysis
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/175130
_version_	1778169859552575488

Oncogenic RAS-induced CK1? drives nuclear FOXO proteolysis

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