Oncogenic RAS-induced CK1? drives nuclear FOXO proteolysis

• Main Authors: Zhang, F, Virshup, D.M, Cheong, J.K
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: casein kinase Ialpha; caspase; nuclear protein; phosphatidylinositol 3 kinase; proteasome; protein FOXO4; protein kinase B; Ras protein; serine; transcription factor FKHRL1; transcription factor FOXO; tumor suppressor protein; unclassified drug; 4-(4-(2,3-dihydrobenzo(1,4)dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide; benzamide derivative; FOXO3 protein, human; FOXO4 protein, human; imidazole derivative; KRAS protein, human; proteasome inhibitor; protein p21; small interfering RNA; transcription factor; apoptosis; Article; cancer cell line; cancer growth; cell mutant; colon cancer; human; human cell; nuclear export; priority journal; protein degradation; protein expression; protein induction; protein phosphorylation; protein processing; regulatory mechanism; signal transduction; antagonists and inhibitors; cell cycle; cell nucleus; drug effect; genetics; metabolism; mutation; neoplasm; pathology; phosphorylation; tumor cell line; Apoptosis; Benzamides; Casein Kinase Ialpha; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Forkhead Box Protein O3; Humans; Imidazoles; Mutation; Neoplasms; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Proteolysis; Proto-Oncogene Proteins p21(ras); RNA, Small Interfering; Serine; Signal Transduction; Transcription Factors
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175130
• Institution: National University of Singapore

10.1038/onc.2017.334