Artesunate activates the intrinsic apoptosis of HCT116 cells through the suppression of fatty acid synthesis and the NF-?B pathway

• Main Authors: Chen, X, Wong, Y.K, Lim, T.K, Lim, W.H, Lin, Q, Wang, J, Hua, Z
• Other Authors: BIOLOGICAL SCIENCES
• Format: Article
• Published: MDPI AG 2020
• Subjects: artemisinin derivative; artesunate; fatty acid; immunoglobulin enhancer binding protein; reactive oxygen metabolite; apoptosis; biological model; biosynthesis; cell proliferation; cell survival; dose response; drug effects; HCT 116 cell line; human; metabolism; mitochondrion; procedures; proteomics; signal transduction; Apoptosis; Artemisinins; Biosynthetic Pathways; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Fatty Acids; HCT116 Cells; Humans; Mitochondria; Models, Biological; NF-kappa B; Proteomics; Reactive Oxygen Species; Signal Transduction
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175156
• Institution: National University of Singapore

10.3390/molecules22081272