Identification of a novel SYK/c-MYC/MALAT1 signaling pathway and its potential therapeutic value in Ewing sarcoma

10.1158/1078-0432.CCR-16-2185

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Main Authors:	Sun, H, Lin, D.-C, Cao, Q, Pang, B, Gae, D.D, Lee, V.K.M, Lim, H.J, Doan, N, Said, J.W, Gery, S, Chow, M, Mayakonda, A, Forscher, C, Tyner, J.W, Koeffler, H.P
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	American Association for Cancer Research Inc. 2020
Subjects:	entospletinib long untranslated RNA MALAT1 Myc protein poloxamer protein kinase B protein kinase Syk small interfering RNA unclassified drug MALAT1 long non-coding RNA, human MYC protein, human SYK protein, human animal experiment animal model animal tissue Article cell proliferation chromatin immunoprecipitation controlled study cytotoxicity DNA microarray drug targeting enzyme inhibition enzyme phosphorylation enzyme reactivation Ewing sarcoma female high throughput screening human human cell luciferase assay molecular library nonhuman polymerase chain reaction system priority journal promoter region signal transduction SYK cMYC MALAT1 signaling pathway transcription regulation administration and dosage animal antagonists and inhibitors drug effect drug screening gene expression regulation genetics molecularly targeted therapy mouse pathology procedures tumor cell line Animals Cell Line, Tumor Cell Proliferation Gene Expression Regulation, Neoplastic High-Throughput Screening Assays Humans Mice Molecular Targeted Therapy Oligonucleotide Array Sequence Analysis Proto-Oncogene Proteins c-myc RNA, Long Noncoding RNA, Small Interfering Sarcoma, Ewing Signal Transduction Small Molecule Libraries Syk Kinase Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/175157
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1751572024-05-08T09:51:53Z Identification of a novel SYK/c-MYC/MALAT1 signaling pathway and its potential therapeutic value in Ewing sarcoma Sun, H Lin, D.-C Cao, Q Pang, B Gae, D.D Lee, V.K.M Lim, H.J Doan, N Said, J.W Gery, S Chow, M Mayakonda, A Forscher, C Tyner, J.W Koeffler, H.P CANCER SCIENCE INSTITUTE OF SINGAPORE PATHOLOGY MEDICINE entospletinib long untranslated RNA MALAT1 Myc protein poloxamer protein kinase B protein kinase Syk small interfering RNA unclassified drug long untranslated RNA MALAT1 long non-coding RNA, human Myc protein MYC protein, human protein kinase Syk SYK protein, human animal experiment animal model animal tissue Article cell proliferation chromatin immunoprecipitation controlled study cytotoxicity DNA microarray drug targeting enzyme inhibition enzyme phosphorylation enzyme reactivation Ewing sarcoma female high throughput screening human human cell luciferase assay molecular library nonhuman polymerase chain reaction system priority journal promoter region signal transduction SYK cMYC MALAT1 signaling pathway transcription regulation administration and dosage animal antagonists and inhibitors drug effect drug screening Ewing sarcoma gene expression regulation genetics molecularly targeted therapy mouse pathology procedures signal transduction tumor cell line Animals Cell Line, Tumor Cell Proliferation Gene Expression Regulation, Neoplastic High-Throughput Screening Assays Humans Mice Molecular Targeted Therapy Oligonucleotide Array Sequence Analysis Proto-Oncogene Proteins c-myc RNA, Long Noncoding RNA, Small Interfering Sarcoma, Ewing Signal Transduction Small Molecule Libraries Syk Kinase Xenograft Model Antitumor Assays 10.1158/1078-0432.CCR-16-2185 Clinical Cancer Research 23 15 4376-4387 2020-09-09T04:18:29Z 2020-09-09T04:18:29Z 2017 Article Sun, H, Lin, D.-C, Cao, Q, Pang, B, Gae, D.D, Lee, V.K.M, Lim, H.J, Doan, N, Said, J.W, Gery, S, Chow, M, Mayakonda, A, Forscher, C, Tyner, J.W, Koeffler, H.P (2017). Identification of a novel SYK/c-MYC/MALAT1 signaling pathway and its potential therapeutic value in Ewing sarcoma. Clinical Cancer Research 23 (15) : 4376-4387. ScholarBank@NUS Repository. https://doi.org/10.1158/1078-0432.CCR-16-2185 1078-0432 https://scholarbank.nus.edu.sg/handle/10635/175157 American Association for Cancer Research Inc. Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	entospletinib long untranslated RNA MALAT1 Myc protein poloxamer protein kinase B protein kinase Syk small interfering RNA unclassified drug long untranslated RNA MALAT1 long non-coding RNA, human Myc protein MYC protein, human protein kinase Syk SYK protein, human animal experiment animal model animal tissue Article cell proliferation chromatin immunoprecipitation controlled study cytotoxicity DNA microarray drug targeting enzyme inhibition enzyme phosphorylation enzyme reactivation Ewing sarcoma female high throughput screening human human cell luciferase assay molecular library nonhuman polymerase chain reaction system priority journal promoter region signal transduction SYK cMYC MALAT1 signaling pathway transcription regulation administration and dosage animal antagonists and inhibitors drug effect drug screening Ewing sarcoma gene expression regulation genetics molecularly targeted therapy mouse pathology procedures signal transduction tumor cell line Animals Cell Line, Tumor Cell Proliferation Gene Expression Regulation, Neoplastic High-Throughput Screening Assays Humans Mice Molecular Targeted Therapy Oligonucleotide Array Sequence Analysis Proto-Oncogene Proteins c-myc RNA, Long Noncoding RNA, Small Interfering Sarcoma, Ewing Signal Transduction Small Molecule Libraries Syk Kinase Xenograft Model Antitumor Assays
spellingShingle	entospletinib long untranslated RNA MALAT1 Myc protein poloxamer protein kinase B protein kinase Syk small interfering RNA unclassified drug long untranslated RNA MALAT1 long non-coding RNA, human Myc protein MYC protein, human protein kinase Syk SYK protein, human animal experiment animal model animal tissue Article cell proliferation chromatin immunoprecipitation controlled study cytotoxicity DNA microarray drug targeting enzyme inhibition enzyme phosphorylation enzyme reactivation Ewing sarcoma female high throughput screening human human cell luciferase assay molecular library nonhuman polymerase chain reaction system priority journal promoter region signal transduction SYK cMYC MALAT1 signaling pathway transcription regulation administration and dosage animal antagonists and inhibitors drug effect drug screening Ewing sarcoma gene expression regulation genetics molecularly targeted therapy mouse pathology procedures signal transduction tumor cell line Animals Cell Line, Tumor Cell Proliferation Gene Expression Regulation, Neoplastic High-Throughput Screening Assays Humans Mice Molecular Targeted Therapy Oligonucleotide Array Sequence Analysis Proto-Oncogene Proteins c-myc RNA, Long Noncoding RNA, Small Interfering Sarcoma, Ewing Signal Transduction Small Molecule Libraries Syk Kinase Xenograft Model Antitumor Assays Sun, H Lin, D.-C Cao, Q Pang, B Gae, D.D Lee, V.K.M Lim, H.J Doan, N Said, J.W Gery, S Chow, M Mayakonda, A Forscher, C Tyner, J.W Koeffler, H.P Identification of a novel SYK/c-MYC/MALAT1 signaling pathway and its potential therapeutic value in Ewing sarcoma
description	10.1158/1078-0432.CCR-16-2185
author2	CANCER SCIENCE INSTITUTE OF SINGAPORE
author_facet	CANCER SCIENCE INSTITUTE OF SINGAPORE Sun, H Lin, D.-C Cao, Q Pang, B Gae, D.D Lee, V.K.M Lim, H.J Doan, N Said, J.W Gery, S Chow, M Mayakonda, A Forscher, C Tyner, J.W Koeffler, H.P
format	Article
author	Sun, H Lin, D.-C Cao, Q Pang, B Gae, D.D Lee, V.K.M Lim, H.J Doan, N Said, J.W Gery, S Chow, M Mayakonda, A Forscher, C Tyner, J.W Koeffler, H.P
author_sort	Sun, H
title	Identification of a novel SYK/c-MYC/MALAT1 signaling pathway and its potential therapeutic value in Ewing sarcoma
title_short	Identification of a novel SYK/c-MYC/MALAT1 signaling pathway and its potential therapeutic value in Ewing sarcoma
title_full	Identification of a novel SYK/c-MYC/MALAT1 signaling pathway and its potential therapeutic value in Ewing sarcoma
title_fullStr	Identification of a novel SYK/c-MYC/MALAT1 signaling pathway and its potential therapeutic value in Ewing sarcoma
title_full_unstemmed	Identification of a novel SYK/c-MYC/MALAT1 signaling pathway and its potential therapeutic value in Ewing sarcoma
title_sort	identification of a novel syk/c-myc/malat1 signaling pathway and its potential therapeutic value in ewing sarcoma
publisher	American Association for Cancer Research Inc.
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/175157
_version_	1800914346086236160

Identification of a novel SYK/c-MYC/MALAT1 signaling pathway and its potential therapeutic value in Ewing sarcoma

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