Identification of a novel SYK/c-MYC/MALAT1 signaling pathway and its potential therapeutic value in Ewing sarcoma

• Main Authors: Sun, H, Lin, D.-C, Cao, Q, Pang, B, Gae, D.D, Lee, V.K.M, Lim, H.J, Doan, N, Said, J.W, Gery, S, Chow, M, Mayakonda, A, Forscher, C, Tyner, J.W, Koeffler, H.P
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: American Association for Cancer Research Inc. 2020
• Subjects: entospletinib; long untranslated RNA; MALAT1; Myc protein; poloxamer; protein kinase B; protein kinase Syk; small interfering RNA; unclassified drug; MALAT1 long non-coding RNA, human; MYC protein, human; SYK protein, human; animal experiment; animal model; animal tissue; Article; cell proliferation; chromatin immunoprecipitation; controlled study; cytotoxicity; DNA microarray; drug targeting; enzyme inhibition; enzyme phosphorylation; enzyme reactivation; Ewing sarcoma; female; high throughput screening; human; human cell; luciferase assay; molecular library; nonhuman; polymerase chain reaction system; priority journal; promoter region; signal transduction; SYK cMYC MALAT1 signaling pathway; transcription regulation; administration and dosage; animal; antagonists and inhibitors; drug effect; drug screening; gene expression regulation; genetics; molecularly targeted therapy; mouse; pathology; procedures; tumor cell line; Animals; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; High-Throughput Screening Assays; Humans; Mice; Molecular Targeted Therapy; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins c-myc; RNA, Long Noncoding; RNA, Small Interfering; Sarcoma, Ewing; Signal Transduction; Small Molecule Libraries; Syk Kinase; Xenograft Model Antitumor Assays
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175157
• Institution: National University of Singapore

10.1158/1078-0432.CCR-16-2185