RRM domain of ALS/FTD-causing FUS characteristic of irreversible unfolding spontaneously self-assembles into amyloid fibrils /631/1647/2258/878/1263 /631/535/878/1263 /101 /101/6 article

RRM domain of ALS/FTD-causing FUS characteristic of irreversible unfolding spontaneously self-assembles into amyloid fibrils /631/1647/2258/878/1263 /631/535/878/1263 /101 /101/6 article

10.1038/s41598-017-01281-7

Saved in:

Bibliographic Details
Main Authors:	Lu, Y, Lim, L, Song, J
Other Authors:	DEPT OF BIOLOGICAL SCIENCES
Format:	Article
Published:	2020
Subjects:	amyloid FUS protein, human RNA binding protein FUS amyotrophic lateral sclerosis chemistry human metabolism nuclear magnetic resonance spectroscopy pathophysiology protein conformation protein domain protein folding protein motif protein multimerization Amino Acid Motifs Amyloid Amyotrophic Lateral Sclerosis Humans Magnetic Resonance Spectroscopy Protein Conformation Protein Domains Protein Folding Protein Multimerization RNA-Binding Protein FUS
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/175192
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	National University of Singapore

Similar Items

MOLECULAR PATHOGENESIS STUDY OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) USING FUSED IN SARCOMA (FUS) PROTEIN
by: LU YIMEI
Published: (2018)

Biomolecular condensates in photosynthesis and metabolism
by: Wunder, Tobias, et al.
Published: (2020)

Synaptic paths to neurodegeneration: The emerging role of TDP-43 and FUS in synaptic functions
by: Ling, S.-C
Published: (2020)

ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43
by: Lim L., et al.
Published: (2020)

Structure of the C-terminal domain of TRADD reveals a novel fold in the death domain superfamily
by: Zhang, N, et al.
Published: (2020)

Structure Function Studies of Vesicle-associated membrane protein-associated protein B (VAPB) associated with Amyotrophic lateral Sclerosis (ALS)
by: LUA SHIXIONG
Published: (2012)

Genetic mutations in RNA-binding proteins and their roles in ALS
by: Kapeli, K, et al.
Published: (2020)

Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex
by: Kristal Kaan, H.Y, et al.
Published: (2020)

Molecular nonlinear dynamics and protein thermal uncertainty quantification
by: Xia, Kelin, et al.
Published: (2016)

Clustering-based approach for predicting motif pairs from protein interaction data
by: Leung, H.C.-M., et al.
Published: (2013)

Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice
by: Shelkovnikova, T.A, et al.
Published: (2020)

Equilibrium folding dynamics of meACP in water, heavy water, and low concentration of urea
by: Zhou Y., et al.
Published: (2020)

STRUCTURAL BASIS FOR ANCHORING HCV REPLICATION COMPLEX ONTO THE HUMAN ER-MEMBRANE: IMPLICATIONS FOR HCV-TRIGGERED ALS PATHOGENESIS
by: GARVITA GUPTA
Published: (2013)

ALS-causing P56S mutation and splicing variation on the hVAPB MSP domain transform its β-sandwich fold into lipid-interacting helical conformations
by: Qin, H., et al.
Published: (2014)

An off-pathway folding intermediate of an acyl carrier protein domain coexists with the folded and unfolded states under native conditions
by: Lim, J., et al.
Published: (2014)

Proteasomal inhibition causes the formation of protein aggregates containing a wide range of proteins, including nitrated proteins
by: Hyun, D.-H., et al.
Published: (2013)

Changes in the folding landscape of the WW domain provide a molecular mechanism for an inherited genetic syndrome
by: Pucheta-Martinez, E, et al.
Published: (2020)

D-SLIMMER: Domain-SLiM interaction motifs miner for sequence based protein-protein interaction data
by: Hugo, W., et al.
Published: (2013)

Long range recognition and selection in IDPs: The interactions of the C-terminus of p53
by: Kannan, S, et al.
Published: (2020)

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis
by: Ling, S.-C., et al.
Published: (2021)

Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
by: Kapeli, K, et al.
Published: (2020)

Biophysical studies and NMR structure of YAP2 WW domain-LATS1 PPxY motif complexes reveal the basis of their interaction
by: Verma, A, et al.
Published: (2020)

NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity
by: Li, C, et al.
Published: (2020)

Resolving the paradox for protein aggregation diseases: NMR structure and dynamics of the membrane-embedded P56S-MSP causing ALS imply a common mechanism for aggregation-prone proteins to attack membranes
by: Song J., et al.
Published: (2020)

Thermostable exoshells fold and stabilize recombinant proteins
by: Deshpande, Siddharth, et al.
Published: (2018)

Why do proteins aggregate? "Intrinsically insoluble proteins"? And "dark mediators"? Revealed by studies on "insoluble proteins"? Solubilized in pure water
by: Song, J
Published: (2020)

Viral Capsid Proteins Are Segregated in Structural Fold Space
by: Cheng S., et al.
Published: (2019)

Discovering interacting domains and motifs in protein-protein interactions
by: Hugo, W., et al.
Published: (2013)

Structural basis of Ornithine Decarboxylase inactivation and accelerated degradation by polyamine sensor Antizyme1
by: Wu, D, et al.
Published: (2020)

Stochastic Roadmap Simulation: An Efficient Representation and Algorithm for Analyzing Molecular Motion
by: Apaydin, M.S., et al.
Published: (2013)

AMYLOID PRECURSOR PROTEIN SIGNALING IN PHYSIOLOGY AND ALZHEIMER?S DISEASE
by: JOANITA BINTE JASMEN
Published: (2016)

Computational analyses of the surface properties of protein-protein interfaces
by: Gruber, J, et al.
Published: (2020)

A GUARDIAN FACTOR THAT PROTECTS FOLDING POLYPEPTIDES FROM PROMISCUOUS DEGRADATION
by: ZHANG SHAN
Published: (2018)

Coherent conformational degrees of freedom as a structural basis for allosteric communication
by: Mitternacht S., et al.
Published: (2019)

Yeast aconitase mitochondrial import is modulated by interactions of its C and N terminal domains and Ssa1/2 (Hsp70)
by: Ben-Menachem, R, et al.
Published: (2020)

The rat ortholog of the presumptive flounder antifreeze enhancer-binding protein is a helicase domain-containing protein
by: Miao, M., et al.
Published: (2014)

Extended loop region of Hcp1 is critical for the assembly and function of type VI secretion system in Burkholderia pseudomallei
by: Lim, Y.T, et al.
Published: (2020)

Cytotoxicity os transthyretin amyloid to peripheral tissue and use of the peripheral tissue for cell based screening of the amyloid inhibitors
by: Porntip Prapunpoj
Published: (2015)

Dysfunction in nonsense-mediated decay, protein homeostasis, mitochondrial function, and brain connectivity in ALS-FUS mice with cognitive deficits
by: Ho, Wan Yun, et al.
Published: (2022)

Characterizing the Conformational Landscape of Flavivirus Fusion Peptides via Simulation and Experiment
by: Marzinek, J.K, et al.
Published: (2020)