Missense mutations in the unfoldase ClpC1 of the caseinolytic protease complex are associated with pyrazinamide resistance in Mycobacterium tuberculosis

• Main Authors: Yee, M, Gopal, P, Dick, T
• Other Authors: SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
• Format: Article
• Published: American Society for Microbiology 2020
• Subjects: clpc1 protein; genomic DNA; isoniazid; messenger RNA; proteasome; protein; pyrazinamide; pyrazinoic acid; rifampicin; unclassified drug; tuberculostatic agent; amino acid substitution; amino terminal sequence; Article; bacterium culture; broth dilution; cell suspension; colony formation; cryopreservation; DNA extraction; hydrolysis; loss of function mutation; missense mutation; Mycobacterium tuberculosis; nonhuman; polymerase chain reaction; priority journal; single nucleotide polymorphism; spontaneous mutation; whole genome sequencing; analogs and derivatives; antibiotic resistance; drug effects; genetics; microbial sensitivity test; mutation; Antitubercular Agents; Drug Resistance, Bacterial; Microbial Sensitivity Tests; Mutation; Mutation, Missense; Pyrazinamide
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175236
• Institution: National University of Singapore

10.1128/AAC.02342-16