Missense mutations in the unfoldase ClpC1 of the caseinolytic protease complex are associated with pyrazinamide resistance in Mycobacterium tuberculosis

10.1128/AAC.02342-16

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Main Authors:	Yee, M, Gopal, P, Dick, T
Other Authors:	SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
Format:	Article
Published:	American Society for Microbiology 2020
Subjects:	clpc1 protein genomic DNA isoniazid messenger RNA proteasome protein pyrazinamide pyrazinoic acid rifampicin unclassified drug tuberculostatic agent amino acid substitution amino terminal sequence Article bacterium culture broth dilution cell suspension colony formation cryopreservation DNA extraction hydrolysis loss of function mutation missense mutation Mycobacterium tuberculosis nonhuman polymerase chain reaction priority journal single nucleotide polymorphism spontaneous mutation whole genome sequencing analogs and derivatives antibiotic resistance drug effects genetics microbial sensitivity test mutation Antitubercular Agents Drug Resistance, Bacterial Microbial Sensitivity Tests Mutation Mutation, Missense Pyrazinamide
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/175236
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1752362024-03-27T08:06:52Z Missense mutations in the unfoldase ClpC1 of the caseinolytic protease complex are associated with pyrazinamide resistance in Mycobacterium tuberculosis Yee, M Gopal, P Dick, T SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH MICROBIOLOGY AND IMMUNOLOGY clpc1 protein genomic DNA isoniazid messenger RNA proteasome protein pyrazinamide pyrazinoic acid rifampicin unclassified drug pyrazinamide tuberculostatic agent amino acid substitution amino terminal sequence Article bacterium culture broth dilution cell suspension colony formation cryopreservation DNA extraction hydrolysis loss of function mutation missense mutation Mycobacterium tuberculosis nonhuman polymerase chain reaction priority journal single nucleotide polymorphism spontaneous mutation whole genome sequencing analogs and derivatives antibiotic resistance drug effects genetics microbial sensitivity test missense mutation mutation Mycobacterium tuberculosis Antitubercular Agents Drug Resistance, Bacterial Microbial Sensitivity Tests Mutation Mutation, Missense Mycobacterium tuberculosis Pyrazinamide 10.1128/AAC.02342-16 Antimicrobial Agents and Chemotherapy 61 2 e02342 2020-09-09T06:26:53Z 2020-09-09T06:26:53Z 2017 Article Yee, M, Gopal, P, Dick, T (2017). Missense mutations in the unfoldase ClpC1 of the caseinolytic protease complex are associated with pyrazinamide resistance in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy 61 (2) : e02342. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.02342-16 0066-4804 https://scholarbank.nus.edu.sg/handle/10635/175236 American Society for Microbiology Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	clpc1 protein genomic DNA isoniazid messenger RNA proteasome protein pyrazinamide pyrazinoic acid rifampicin unclassified drug pyrazinamide tuberculostatic agent amino acid substitution amino terminal sequence Article bacterium culture broth dilution cell suspension colony formation cryopreservation DNA extraction hydrolysis loss of function mutation missense mutation Mycobacterium tuberculosis nonhuman polymerase chain reaction priority journal single nucleotide polymorphism spontaneous mutation whole genome sequencing analogs and derivatives antibiotic resistance drug effects genetics microbial sensitivity test missense mutation mutation Mycobacterium tuberculosis Antitubercular Agents Drug Resistance, Bacterial Microbial Sensitivity Tests Mutation Mutation, Missense Mycobacterium tuberculosis Pyrazinamide
spellingShingle	clpc1 protein genomic DNA isoniazid messenger RNA proteasome protein pyrazinamide pyrazinoic acid rifampicin unclassified drug pyrazinamide tuberculostatic agent amino acid substitution amino terminal sequence Article bacterium culture broth dilution cell suspension colony formation cryopreservation DNA extraction hydrolysis loss of function mutation missense mutation Mycobacterium tuberculosis nonhuman polymerase chain reaction priority journal single nucleotide polymorphism spontaneous mutation whole genome sequencing analogs and derivatives antibiotic resistance drug effects genetics microbial sensitivity test missense mutation mutation Mycobacterium tuberculosis Antitubercular Agents Drug Resistance, Bacterial Microbial Sensitivity Tests Mutation Mutation, Missense Mycobacterium tuberculosis Pyrazinamide Yee, M Gopal, P Dick, T Missense mutations in the unfoldase ClpC1 of the caseinolytic protease complex are associated with pyrazinamide resistance in Mycobacterium tuberculosis
description	10.1128/AAC.02342-16
author2	SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
author_facet	SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH Yee, M Gopal, P Dick, T
format	Article
author	Yee, M Gopal, P Dick, T
author_sort	Yee, M
title	Missense mutations in the unfoldase ClpC1 of the caseinolytic protease complex are associated with pyrazinamide resistance in Mycobacterium tuberculosis
title_short	Missense mutations in the unfoldase ClpC1 of the caseinolytic protease complex are associated with pyrazinamide resistance in Mycobacterium tuberculosis
title_full	Missense mutations in the unfoldase ClpC1 of the caseinolytic protease complex are associated with pyrazinamide resistance in Mycobacterium tuberculosis
title_fullStr	Missense mutations in the unfoldase ClpC1 of the caseinolytic protease complex are associated with pyrazinamide resistance in Mycobacterium tuberculosis
title_full_unstemmed	Missense mutations in the unfoldase ClpC1 of the caseinolytic protease complex are associated with pyrazinamide resistance in Mycobacterium tuberculosis
title_sort	missense mutations in the unfoldase clpc1 of the caseinolytic protease complex are associated with pyrazinamide resistance in mycobacterium tuberculosis
publisher	American Society for Microbiology
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/175236
_version_	1795301116070592512

Missense mutations in the unfoldase ClpC1 of the caseinolytic protease complex are associated with pyrazinamide resistance in Mycobacterium tuberculosis

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