Missense mutations in the unfoldase ClpC1 of the caseinolytic protease complex are associated with pyrazinamide resistance in Mycobacterium tuberculosis

Missense mutations in the unfoldase ClpC1 of the caseinolytic protease complex are associated with pyrazinamide resistance in Mycobacterium tuberculosis

10.1128/AAC.02342-16

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Bibliographic Details
Main Authors:	Yee, M, Gopal, P, Dick, T
Other Authors:	SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
Format:	Article
Published:	American Society for Microbiology 2020
Subjects:	clpc1 protein genomic DNA isoniazid messenger RNA proteasome protein pyrazinamide pyrazinoic acid rifampicin unclassified drug tuberculostatic agent amino acid substitution amino terminal sequence Article bacterium culture broth dilution cell suspension colony formation cryopreservation DNA extraction hydrolysis loss of function mutation missense mutation Mycobacterium tuberculosis nonhuman polymerase chain reaction priority journal single nucleotide polymorphism spontaneous mutation whole genome sequencing analogs and derivatives antibiotic resistance drug effects genetics microbial sensitivity test mutation Antitubercular Agents Drug Resistance, Bacterial Microbial Sensitivity Tests Mutation Mutation, Missense Pyrazinamide
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/175236
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Institution:	National University of Singapore

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