Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion

10.1038/ncomms10380

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Main Authors:	Yamamoto Y., Wang X., Bertrand D., Kern F., Zhang T., Duleba M., Srivastava S., Khor C.C., Hu Y., Wilson L.H., Blaszyk H., Rolshud D., Teh M., Liu J., Howitt B.E., Vincent M., Crum C.P., Nagarajan N., Ho K.Y., McKeon F., Xian W.
Other Authors:	DEPARTMENT OF COMPUTER SCIENCE
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	protein p53 protein tyrosine kinase cells and cell components enzyme activity gene expression genomics lesion mutation spectrum tumor adult adult stem cell Article Barrett esophagus cancer growth cancer patient cancer risk cancer stem cell cell differentiation cell isolation copy number variation endoscopic biopsy esophageal adenocarcinoma gene amplification gene frequency gene mutation human human cell human tissue immunohistochemistry in vitro study mutational analysis precancer proto oncogene single nucleotide polymorphism xenograft animal cell culture genetics male metabolism mouse pathology stem cell tumor cell culture Animals Barrett Esophagus Cell Differentiation Cells, Cultured Humans Male Mice Mutation Precancerous Conditions Stem Cells Tumor Cells, Cultured
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/175443
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1754432024-04-25T08:06:55Z Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion Yamamoto Y. Wang X. Bertrand D. Kern F. Zhang T. Duleba M. Srivastava S. Khor C.C. Hu Y. Wilson L.H. Blaszyk H. Rolshud D. Teh M. Liu J. Howitt B.E. Vincent M. Crum C.P. Nagarajan N. Ho K.Y. McKeon F. Xian W. DEPARTMENT OF COMPUTER SCIENCE protein p53 protein tyrosine kinase cells and cell components enzyme activity gene expression genomics lesion mutation spectrum tumor adult adult stem cell Article Barrett esophagus cancer growth cancer patient cancer risk cancer stem cell cell differentiation cell isolation copy number variation endoscopic biopsy esophageal adenocarcinoma gene amplification gene frequency gene mutation human human cell human tissue immunohistochemistry in vitro study mutational analysis precancer proto oncogene single nucleotide polymorphism xenograft animal Barrett esophagus cell culture genetics male metabolism mouse mutation pathology precancer stem cell tumor cell culture Animals Barrett Esophagus Cell Differentiation Cells, Cultured Humans Male Mice Mutation Precancerous Conditions Stem Cells Tumor Cells, Cultured 10.1038/ncomms10380 Nature Communications 7 10380 2020-09-10T01:42:09Z 2020-09-10T01:42:09Z 2016 Article Yamamoto Y., Wang X., Bertrand D., Kern F., Zhang T., Duleba M., Srivastava S., Khor C.C., Hu Y., Wilson L.H., Blaszyk H., Rolshud D., Teh M., Liu J., Howitt B.E., Vincent M., Crum C.P., Nagarajan N., Ho K.Y., McKeon F., Xian W. (2016). Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion. Nature Communications 7 : 10380. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms10380 20411723 https://scholarbank.nus.edu.sg/handle/10635/175443 Nature Publishing Group Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	protein p53 protein tyrosine kinase cells and cell components enzyme activity gene expression genomics lesion mutation spectrum tumor adult adult stem cell Article Barrett esophagus cancer growth cancer patient cancer risk cancer stem cell cell differentiation cell isolation copy number variation endoscopic biopsy esophageal adenocarcinoma gene amplification gene frequency gene mutation human human cell human tissue immunohistochemistry in vitro study mutational analysis precancer proto oncogene single nucleotide polymorphism xenograft animal Barrett esophagus cell culture genetics male metabolism mouse mutation pathology precancer stem cell tumor cell culture Animals Barrett Esophagus Cell Differentiation Cells, Cultured Humans Male Mice Mutation Precancerous Conditions Stem Cells Tumor Cells, Cultured
spellingShingle	protein p53 protein tyrosine kinase cells and cell components enzyme activity gene expression genomics lesion mutation spectrum tumor adult adult stem cell Article Barrett esophagus cancer growth cancer patient cancer risk cancer stem cell cell differentiation cell isolation copy number variation endoscopic biopsy esophageal adenocarcinoma gene amplification gene frequency gene mutation human human cell human tissue immunohistochemistry in vitro study mutational analysis precancer proto oncogene single nucleotide polymorphism xenograft animal Barrett esophagus cell culture genetics male metabolism mouse mutation pathology precancer stem cell tumor cell culture Animals Barrett Esophagus Cell Differentiation Cells, Cultured Humans Male Mice Mutation Precancerous Conditions Stem Cells Tumor Cells, Cultured Yamamoto Y. Wang X. Bertrand D. Kern F. Zhang T. Duleba M. Srivastava S. Khor C.C. Hu Y. Wilson L.H. Blaszyk H. Rolshud D. Teh M. Liu J. Howitt B.E. Vincent M. Crum C.P. Nagarajan N. Ho K.Y. McKeon F. Xian W. Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion
description	10.1038/ncomms10380
author2	DEPARTMENT OF COMPUTER SCIENCE
author_facet	DEPARTMENT OF COMPUTER SCIENCE Yamamoto Y. Wang X. Bertrand D. Kern F. Zhang T. Duleba M. Srivastava S. Khor C.C. Hu Y. Wilson L.H. Blaszyk H. Rolshud D. Teh M. Liu J. Howitt B.E. Vincent M. Crum C.P. Nagarajan N. Ho K.Y. McKeon F. Xian W.
format	Article
author	Yamamoto Y. Wang X. Bertrand D. Kern F. Zhang T. Duleba M. Srivastava S. Khor C.C. Hu Y. Wilson L.H. Blaszyk H. Rolshud D. Teh M. Liu J. Howitt B.E. Vincent M. Crum C.P. Nagarajan N. Ho K.Y. McKeon F. Xian W.
author_sort	Yamamoto Y.
title	Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion
title_short	Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion
title_full	Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion
title_fullStr	Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion
title_full_unstemmed	Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion
title_sort	mutational spectrum of barrett's stem cells suggests paths to initiation of a precancerous lesion
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/175443
_version_	1800914369013350400

Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion

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