Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion

• Main Authors: Yamamoto Y., Wang X., Bertrand D., Kern F., Zhang T., Duleba M., Srivastava S., Khor C.C., Hu Y., Wilson L.H., Blaszyk H., Rolshud D., Teh M., Liu J., Howitt B.E., Vincent M., Crum C.P., Nagarajan N., Ho K.Y., McKeon F., Xian W.
• Other Authors: DEPARTMENT OF COMPUTER SCIENCE
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: protein p53; protein tyrosine kinase; cells and cell components; enzyme activity; gene expression; genomics; lesion; mutation; spectrum; tumor; adult; adult stem cell; Article; Barrett esophagus; cancer growth; cancer patient; cancer risk; cancer stem cell; cell differentiation; cell isolation; copy number variation; endoscopic biopsy; esophageal adenocarcinoma; gene amplification; gene frequency; gene mutation; human; human cell; human tissue; immunohistochemistry; in vitro study; mutational analysis; precancer; proto oncogene; single nucleotide polymorphism; xenograft; animal; cell culture; genetics; male; metabolism; mouse; pathology; stem cell; tumor cell culture; Animals; Barrett Esophagus; Cell Differentiation; Cells, Cultured; Humans; Male; Mice; Mutation; Precancerous Conditions; Stem Cells; Tumor Cells, Cultured
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175443
• Institution: National University of Singapore

10.1038/ncomms10380