RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity

10.1038/bcj.2015.105

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Main Authors:	Chin, D.W.L, Sakurai, M, Nah, G.S.S, Du, L, Jacob, B, Yokomizo, T, Matsumura, T, Suda, T, Huang, G, Fu, X.-Y, Ito, Y, Nakajima, H, Osato, M
Other Authors:	MEDICINE
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	granulocyte colony stimulating factor granulocyte macrophage colony stimulating factor interleukin 3 interleukin 6 protein Pias3 regulator protein STAT3 protein transcription factor RUNX1 unclassified drug chaperone chemokine receptor CXCR4 cytokine PIAS3 protein, human protein binding protein inhibitor of activated STAT animal cell animal experiment Article bone marrow cell cell differentiation controlled study haploinsufficiency hematopoiesis hematopoietic cell human human cell in vitro study leukemogenesis mouse nonhuman point mutation protein expression protein phosphorylation protein protein interaction signal transduction stem cell expansion stem cell mobilization thrombocyte disorder acute myeloid leukemia animal disease model drug effects drug resistance gene expression regulation genetic predisposition genetics genotype hematopoietic stem cell metabolism mutation pathology phosphorylation Animals Blood Platelet Disorders Bone Marrow Cells Core Binding Factor Alpha 2 Subunit Cytokines Disease Models, Animal Drug Resistance Gene Expression Regulation, Leukemic Genetic Predisposition to Disease Genotype Granulocyte Colony-Stimulating Factor Haploinsufficiency Hematopoietic Stem Cells Humans Leukemia, Myeloid, Acute Mice Molecular Chaperones Mutation Phosphorylation Protein Binding Protein Inhibitors of Activated STAT Receptors, CXCR4 Signal Transduction STAT3 Transcription Factor
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/175447
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1754472024-11-15T08:39:09Z RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity Chin, D.W.L Sakurai, M Nah, G.S.S Du, L Jacob, B Yokomizo, T Matsumura, T Suda, T Huang, G Fu, X.-Y Ito, Y Nakajima, H Osato, M MEDICINE CANCER SCIENCE INSTITUTE OF SINGAPORE DUKE-NUS MEDICAL SCHOOL BIOCHEMISTRY granulocyte colony stimulating factor granulocyte macrophage colony stimulating factor interleukin 3 interleukin 6 protein Pias3 regulator protein STAT3 protein transcription factor RUNX1 unclassified drug chaperone chemokine receptor CXCR4 cytokine granulocyte colony stimulating factor PIAS3 protein, human protein binding protein inhibitor of activated STAT STAT3 protein transcription factor RUNX1 animal cell animal experiment Article bone marrow cell cell differentiation controlled study haploinsufficiency hematopoiesis hematopoietic cell human human cell in vitro study leukemogenesis mouse nonhuman point mutation protein expression protein phosphorylation protein protein interaction signal transduction stem cell expansion stem cell mobilization thrombocyte disorder acute myeloid leukemia animal disease model drug effects drug resistance gene expression regulation genetic predisposition genetics genotype hematopoietic stem cell metabolism mutation pathology phosphorylation Animals Blood Platelet Disorders Bone Marrow Cells Core Binding Factor Alpha 2 Subunit Cytokines Disease Models, Animal Drug Resistance Gene Expression Regulation, Leukemic Genetic Predisposition to Disease Genotype Granulocyte Colony-Stimulating Factor Haploinsufficiency Hematopoietic Stem Cells Humans Leukemia, Myeloid, Acute Mice Molecular Chaperones Mutation Phosphorylation Protein Binding Protein Inhibitors of Activated STAT Receptors, CXCR4 Signal Transduction STAT3 Transcription Factor 10.1038/bcj.2015.105 Blood Cancer Journal 6 e379 2020-09-10T01:43:07Z 2020-09-10T01:43:07Z 2016 Article Chin, D.W.L, Sakurai, M, Nah, G.S.S, Du, L, Jacob, B, Yokomizo, T, Matsumura, T, Suda, T, Huang, G, Fu, X.-Y, Ito, Y, Nakajima, H, Osato, M (2016). RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity. Blood Cancer Journal 6 : e379. ScholarBank@NUS Repository. https://doi.org/10.1038/bcj.2015.105 20445385 https://scholarbank.nus.edu.sg/handle/10635/175447 Nature Publishing Group Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	granulocyte colony stimulating factor granulocyte macrophage colony stimulating factor interleukin 3 interleukin 6 protein Pias3 regulator protein STAT3 protein transcription factor RUNX1 unclassified drug chaperone chemokine receptor CXCR4 cytokine granulocyte colony stimulating factor PIAS3 protein, human protein binding protein inhibitor of activated STAT STAT3 protein transcription factor RUNX1 animal cell animal experiment Article bone marrow cell cell differentiation controlled study haploinsufficiency hematopoiesis hematopoietic cell human human cell in vitro study leukemogenesis mouse nonhuman point mutation protein expression protein phosphorylation protein protein interaction signal transduction stem cell expansion stem cell mobilization thrombocyte disorder acute myeloid leukemia animal disease model drug effects drug resistance gene expression regulation genetic predisposition genetics genotype hematopoietic stem cell metabolism mutation pathology phosphorylation Animals Blood Platelet Disorders Bone Marrow Cells Core Binding Factor Alpha 2 Subunit Cytokines Disease Models, Animal Drug Resistance Gene Expression Regulation, Leukemic Genetic Predisposition to Disease Genotype Granulocyte Colony-Stimulating Factor Haploinsufficiency Hematopoietic Stem Cells Humans Leukemia, Myeloid, Acute Mice Molecular Chaperones Mutation Phosphorylation Protein Binding Protein Inhibitors of Activated STAT Receptors, CXCR4 Signal Transduction STAT3 Transcription Factor
spellingShingle	granulocyte colony stimulating factor granulocyte macrophage colony stimulating factor interleukin 3 interleukin 6 protein Pias3 regulator protein STAT3 protein transcription factor RUNX1 unclassified drug chaperone chemokine receptor CXCR4 cytokine granulocyte colony stimulating factor PIAS3 protein, human protein binding protein inhibitor of activated STAT STAT3 protein transcription factor RUNX1 animal cell animal experiment Article bone marrow cell cell differentiation controlled study haploinsufficiency hematopoiesis hematopoietic cell human human cell in vitro study leukemogenesis mouse nonhuman point mutation protein expression protein phosphorylation protein protein interaction signal transduction stem cell expansion stem cell mobilization thrombocyte disorder acute myeloid leukemia animal disease model drug effects drug resistance gene expression regulation genetic predisposition genetics genotype hematopoietic stem cell metabolism mutation pathology phosphorylation Animals Blood Platelet Disorders Bone Marrow Cells Core Binding Factor Alpha 2 Subunit Cytokines Disease Models, Animal Drug Resistance Gene Expression Regulation, Leukemic Genetic Predisposition to Disease Genotype Granulocyte Colony-Stimulating Factor Haploinsufficiency Hematopoietic Stem Cells Humans Leukemia, Myeloid, Acute Mice Molecular Chaperones Mutation Phosphorylation Protein Binding Protein Inhibitors of Activated STAT Receptors, CXCR4 Signal Transduction STAT3 Transcription Factor Chin, D.W.L Sakurai, M Nah, G.S.S Du, L Jacob, B Yokomizo, T Matsumura, T Suda, T Huang, G Fu, X.-Y Ito, Y Nakajima, H Osato, M RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity
description	10.1038/bcj.2015.105
author2	MEDICINE
author_facet	MEDICINE Chin, D.W.L Sakurai, M Nah, G.S.S Du, L Jacob, B Yokomizo, T Matsumura, T Suda, T Huang, G Fu, X.-Y Ito, Y Nakajima, H Osato, M
format	Article
author	Chin, D.W.L Sakurai, M Nah, G.S.S Du, L Jacob, B Yokomizo, T Matsumura, T Suda, T Huang, G Fu, X.-Y Ito, Y Nakajima, H Osato, M
author_sort	Chin, D.W.L
title	RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity
title_short	RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity
title_full	RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity
title_fullStr	RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity
title_full_unstemmed	RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity
title_sort	runx1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/175447
_version_	1821226126730592256

RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity

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