RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity

• Main Authors: Chin, D.W.L, Sakurai, M, Nah, G.S.S, Du, L, Jacob, B, Yokomizo, T, Matsumura, T, Suda, T, Huang, G, Fu, X.-Y, Ito, Y, Nakajima, H, Osato, M
• Other Authors: MEDICINE
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: granulocyte colony stimulating factor; granulocyte macrophage colony stimulating factor; interleukin 3; interleukin 6; protein Pias3; regulator protein; STAT3 protein; transcription factor RUNX1; unclassified drug; chaperone; chemokine receptor CXCR4; cytokine; PIAS3 protein, human; protein binding; protein inhibitor of activated STAT; animal cell; animal experiment; Article; bone marrow cell; cell differentiation; controlled study; haploinsufficiency; hematopoiesis; hematopoietic cell; human; human cell; in vitro study; leukemogenesis; mouse; nonhuman; point mutation; protein expression; protein phosphorylation; protein protein interaction; signal transduction; stem cell expansion; stem cell mobilization; thrombocyte disorder; acute myeloid leukemia; animal; disease model; drug effects; drug resistance; gene expression regulation; genetic predisposition; genetics; genotype; hematopoietic stem cell; metabolism; mutation; pathology; phosphorylation; Animals; Blood Platelet Disorders; Bone Marrow Cells; Core Binding Factor Alpha 2 Subunit; Cytokines; Disease Models, Animal; Drug Resistance; Gene Expression Regulation, Leukemic; Genetic Predisposition to Disease; Genotype; Granulocyte Colony-Stimulating Factor; Haploinsufficiency; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Mice; Molecular Chaperones; Mutation; Phosphorylation; Protein Binding; Protein Inhibitors of Activated STAT; Receptors, CXCR4; Signal Transduction; STAT3 Transcription Factor
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175447
• Institution: National University of Singapore

10.1038/bcj.2015.105